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High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

Ras proteins are small GTPases that act as signal transducers between cell surface receptors and several intracellular signaling cascades. They contain highly homologous catalytic domains and flexible C-terminal hypervariable regions (HVRs) that differ across Ras isoforms. KRAS is among the most fre...

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Detalles Bibliográficos
Autores principales:	Chavan, Tanmay S., Jang, Hyunbum, Khavrutskii, Lyuba, Abraham, Sherwin J., Banerjee, Avik, Freed, Benjamin C., Johannessen, Liv, Tarasov, Sergey G., Gaponenko, Vadim, Nussinov, Ruth, Tarasova, Nadya I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society 2015
Materias:	Proteins and Nucleic Acids
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699860/ https://www.ncbi.nlm.nih.gov/pubmed/26682817 http://dx.doi.org/10.1016/j.bpj.2015.09.034

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