MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease

Membrane-type 5-matrix metalloproteinase (MT5-MMP) is a proteinase mainly expressed in the nervous system with emerging roles in brain pathophysiology. The implication of MT5-MMP in Alzheimer’s disease (AD), notably its interplay with the amyloidogenic process, remains elusive. Accordingly, we cross...

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Detalles Bibliográficos
Autores principales: Baranger, Kévin, Marchalant, Yannick, Bonnet, Amandine E., Crouzin, Nadine, Carrete, Alex, Paumier, Jean-Michel, Py, Nathalie A., Bernard, Anne, Bauer, Charlotte, Charrat, Eliane, Moschke, Katrin, Seiki, Mothoharu, Vignes, Michel, Lichtenthaler, Stefan F., Checler, Frédéric, Khrestchatisky, Michel, Rivera, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700096/
https://www.ncbi.nlm.nih.gov/pubmed/26202697
http://dx.doi.org/10.1007/s00018-015-1992-1

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