Successful Treatment with Intravenous Cyclophosphamide for Refractory Adult-Onset Still's Disease

We report a 64-year-old female case of intractable adult-onset Still's disease (AOSD). Initial high-dose steroid therapy combined with cyclosporin A was ineffective against macrophage-activation syndrome (MAS), which was accompanied by the systemic type of AOSD. Treatment for MAS with intraveno...

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Autores principales: Tsuji, Yoshika, Iwanaga, Nozomi, Adachi, Anna, Tsunozaki, Kinuyo, Izumi, Yasumori, Moriwaki, Yuji, Kurohama, Kazuhiro, Ito, Masahiro, Kawakami, Atsushi, Migita, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700153/
https://www.ncbi.nlm.nih.gov/pubmed/26798538
http://dx.doi.org/10.1155/2015/163952
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author Tsuji, Yoshika
Iwanaga, Nozomi
Adachi, Anna
Tsunozaki, Kinuyo
Izumi, Yasumori
Moriwaki, Yuji
Kurohama, Kazuhiro
Ito, Masahiro
Kawakami, Atsushi
Migita, Kiyoshi
author_facet Tsuji, Yoshika
Iwanaga, Nozomi
Adachi, Anna
Tsunozaki, Kinuyo
Izumi, Yasumori
Moriwaki, Yuji
Kurohama, Kazuhiro
Ito, Masahiro
Kawakami, Atsushi
Migita, Kiyoshi
author_sort Tsuji, Yoshika
collection PubMed
description We report a 64-year-old female case of intractable adult-onset Still's disease (AOSD). Initial high-dose steroid therapy combined with cyclosporin A was ineffective against macrophage-activation syndrome (MAS), which was accompanied by the systemic type of AOSD. Treatment for MAS with intravenous cyclophosphamide resulted in remission of AOSD and a reduction in the high doses of steroids. Efficacy of biologics against MAS in AOSD is unclear. Cyclophosphamide, a conventional cytotoxic agent, should be considered as one of the therapeutic options for refractory types of AOSD with MAS.
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spelling pubmed-47001532016-01-21 Successful Treatment with Intravenous Cyclophosphamide for Refractory Adult-Onset Still's Disease Tsuji, Yoshika Iwanaga, Nozomi Adachi, Anna Tsunozaki, Kinuyo Izumi, Yasumori Moriwaki, Yuji Kurohama, Kazuhiro Ito, Masahiro Kawakami, Atsushi Migita, Kiyoshi Case Rep Rheumatol Case Report We report a 64-year-old female case of intractable adult-onset Still's disease (AOSD). Initial high-dose steroid therapy combined with cyclosporin A was ineffective against macrophage-activation syndrome (MAS), which was accompanied by the systemic type of AOSD. Treatment for MAS with intravenous cyclophosphamide resulted in remission of AOSD and a reduction in the high doses of steroids. Efficacy of biologics against MAS in AOSD is unclear. Cyclophosphamide, a conventional cytotoxic agent, should be considered as one of the therapeutic options for refractory types of AOSD with MAS. Hindawi Publishing Corporation 2015 2015-12-22 /pmc/articles/PMC4700153/ /pubmed/26798538 http://dx.doi.org/10.1155/2015/163952 Text en Copyright © 2015 Yoshika Tsuji et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tsuji, Yoshika
Iwanaga, Nozomi
Adachi, Anna
Tsunozaki, Kinuyo
Izumi, Yasumori
Moriwaki, Yuji
Kurohama, Kazuhiro
Ito, Masahiro
Kawakami, Atsushi
Migita, Kiyoshi
Successful Treatment with Intravenous Cyclophosphamide for Refractory Adult-Onset Still's Disease
title Successful Treatment with Intravenous Cyclophosphamide for Refractory Adult-Onset Still's Disease
title_full Successful Treatment with Intravenous Cyclophosphamide for Refractory Adult-Onset Still's Disease
title_fullStr Successful Treatment with Intravenous Cyclophosphamide for Refractory Adult-Onset Still's Disease
title_full_unstemmed Successful Treatment with Intravenous Cyclophosphamide for Refractory Adult-Onset Still's Disease
title_short Successful Treatment with Intravenous Cyclophosphamide for Refractory Adult-Onset Still's Disease
title_sort successful treatment with intravenous cyclophosphamide for refractory adult-onset still's disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700153/
https://www.ncbi.nlm.nih.gov/pubmed/26798538
http://dx.doi.org/10.1155/2015/163952
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