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Cord Blood as a Source of Natural Killer Cells
Cord blood (CB) offers several unique advantages as a graft source for hematopoietic stem cell transplantation (HSCT). The risk of relapse and graft vs. host disease after cord blood transplantation (CBT) is lower than what is typically observed after other graft sources with a similar degree of hum...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700256/ https://www.ncbi.nlm.nih.gov/pubmed/26779484 http://dx.doi.org/10.3389/fmed.2015.00093 |
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author | Mehta, Rohtesh S. Shpall, Elizabeth J. Rezvani, Katayoun |
author_facet | Mehta, Rohtesh S. Shpall, Elizabeth J. Rezvani, Katayoun |
author_sort | Mehta, Rohtesh S. |
collection | PubMed |
description | Cord blood (CB) offers several unique advantages as a graft source for hematopoietic stem cell transplantation (HSCT). The risk of relapse and graft vs. host disease after cord blood transplantation (CBT) is lower than what is typically observed after other graft sources with a similar degree of human leukocyte antigen mismatch. Natural killer (NK) cells have a well-defined role in both innate and adaptive immunity and as the first lymphocytes to reconstitute after HSCT and CBT, and they play a significant role in protection against early relapse. In this article, we highlight the uses of CB NK cells in transplantation and adoptive immunotherapy. First, we will describe differences in the phenotype and functional characteristics of NK cells in CB as compared with peripheral blood. Then, we will review some of the obstacles we face in using resting CB NK cells for adoptive immunotherapy, and discuss methods to overcome them. We will review the current literature on killer-cell immunoglobulin-like receptors ligand mismatch and outcomes after CBT. Finally, we will touch on current strategies for the use of CB NK cells in cellular immunotherapy. |
format | Online Article Text |
id | pubmed-4700256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47002562016-01-15 Cord Blood as a Source of Natural Killer Cells Mehta, Rohtesh S. Shpall, Elizabeth J. Rezvani, Katayoun Front Med (Lausanne) Medicine Cord blood (CB) offers several unique advantages as a graft source for hematopoietic stem cell transplantation (HSCT). The risk of relapse and graft vs. host disease after cord blood transplantation (CBT) is lower than what is typically observed after other graft sources with a similar degree of human leukocyte antigen mismatch. Natural killer (NK) cells have a well-defined role in both innate and adaptive immunity and as the first lymphocytes to reconstitute after HSCT and CBT, and they play a significant role in protection against early relapse. In this article, we highlight the uses of CB NK cells in transplantation and adoptive immunotherapy. First, we will describe differences in the phenotype and functional characteristics of NK cells in CB as compared with peripheral blood. Then, we will review some of the obstacles we face in using resting CB NK cells for adoptive immunotherapy, and discuss methods to overcome them. We will review the current literature on killer-cell immunoglobulin-like receptors ligand mismatch and outcomes after CBT. Finally, we will touch on current strategies for the use of CB NK cells in cellular immunotherapy. Frontiers Media S.A. 2016-01-05 /pmc/articles/PMC4700256/ /pubmed/26779484 http://dx.doi.org/10.3389/fmed.2015.00093 Text en Copyright © 2016 Mehta, Shpall and Rezvani. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Mehta, Rohtesh S. Shpall, Elizabeth J. Rezvani, Katayoun Cord Blood as a Source of Natural Killer Cells |
title | Cord Blood as a Source of Natural Killer Cells |
title_full | Cord Blood as a Source of Natural Killer Cells |
title_fullStr | Cord Blood as a Source of Natural Killer Cells |
title_full_unstemmed | Cord Blood as a Source of Natural Killer Cells |
title_short | Cord Blood as a Source of Natural Killer Cells |
title_sort | cord blood as a source of natural killer cells |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700256/ https://www.ncbi.nlm.nih.gov/pubmed/26779484 http://dx.doi.org/10.3389/fmed.2015.00093 |
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