Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, open-label and double-blind, dose-escalation trial, and a nested, randomised, double-blind, placebo-controlled trial

BACKGROUND: The 2014 west African Zaire Ebola virus epidemic prompted worldwide partners to accelerate clinical development of replication-defective chimpanzee adenovirus 3 vector vaccine expressing Zaire Ebola virus glycoprotein (ChAd3-EBO-Z). We aimed to investigate the safety, tolerability, and i...

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Detalles Bibliográficos
Autores principales: Tapia, Milagritos D, Sow, Samba O, Lyke, Kirsten E, Haidara, Fadima Cheick, Diallo, Fatoumata, Doumbia, Moussa, Traore, Awa, Coulibaly, Flanon, Kodio, Mamoudou, Onwuchekwa, Uma, Sztein, Marcelo B, Wahid, Rezwanul, Campbell, James D, Kieny, Marie-Paule, Moorthy, Vasee, Imoukhuede, Egeruan B, Rampling, Tommy, Roman, Francois, De Ryck, Iris, Bellamy, Abbie R, Dally, Len, Mbaya, Olivier Tshiani, Ploquin, Aurélie, Zhou, Yan, Stanley, Daphne A, Bailer, Robert, Koup, Richard A, Roederer, Mario, Ledgerwood, Julie, Hill, Adrian V S, Ballou, W Ripley, Sullivan, Nancy, Graham, Barney, Levine, Myron M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science ;, The Lancet Pub. Group 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700389/
https://www.ncbi.nlm.nih.gov/pubmed/26546548
http://dx.doi.org/10.1016/S1473-3099(15)00362-X

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