The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a lipid and protein phosphatase, and both activities are necessary for its role as a tumour suppressor. PTEN activity is controlled by phosphorylation of its intrinsically disordered C-terminal tail. A recently discovered variant of...

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Detalles Bibliográficos
Autores principales: Masson, Glenn R., Perisic, Olga, Burke, John E., Williams, Roger L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700475/
https://www.ncbi.nlm.nih.gov/pubmed/26527737
http://dx.doi.org/10.1042/BJ20150931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700475/
https://www.ncbi.nlm.nih.gov/pubmed/26527737
http://dx.doi.org/10.1042/BJ20150931

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