Cbx4: A new guardian of p63’s domain of epidermal control

Epigenetic regulators are essential for cell lineage choices during development. In this issue, Mardaryev et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506065) show that Polycomb subunit Cbx4 acts downstream of transcriptional regulator p63 to maintain epidermal progenitor identity an...

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Detalles Bibliográficos
Autores principales: Cohen, Idan, Ezhkova, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700485/
https://www.ncbi.nlm.nih.gov/pubmed/26711501
http://dx.doi.org/10.1083/jcb.201512032
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author Cohen, Idan
Ezhkova, Elena
author_facet Cohen, Idan
Ezhkova, Elena
author_sort Cohen, Idan
collection PubMed
description Epigenetic regulators are essential for cell lineage choices during development. In this issue, Mardaryev et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506065) show that Polycomb subunit Cbx4 acts downstream of transcriptional regulator p63 to maintain epidermal progenitor identity and proliferation in the developing epidermis via Polycomb-dependent and -independent SUMO E3 ligase activities.
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spelling pubmed-47004852016-07-04 Cbx4: A new guardian of p63’s domain of epidermal control Cohen, Idan Ezhkova, Elena J Cell Biol Reviews Epigenetic regulators are essential for cell lineage choices during development. In this issue, Mardaryev et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506065) show that Polycomb subunit Cbx4 acts downstream of transcriptional regulator p63 to maintain epidermal progenitor identity and proliferation in the developing epidermis via Polycomb-dependent and -independent SUMO E3 ligase activities. The Rockefeller University Press 2016-01-04 /pmc/articles/PMC4700485/ /pubmed/26711501 http://dx.doi.org/10.1083/jcb.201512032 Text en © 2016 Cohen and Ezhkova This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Cohen, Idan
Ezhkova, Elena
Cbx4: A new guardian of p63’s domain of epidermal control
title Cbx4: A new guardian of p63’s domain of epidermal control
title_full Cbx4: A new guardian of p63’s domain of epidermal control
title_fullStr Cbx4: A new guardian of p63’s domain of epidermal control
title_full_unstemmed Cbx4: A new guardian of p63’s domain of epidermal control
title_short Cbx4: A new guardian of p63’s domain of epidermal control
title_sort cbx4: a new guardian of p63’s domain of epidermal control
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700485/
https://www.ncbi.nlm.nih.gov/pubmed/26711501
http://dx.doi.org/10.1083/jcb.201512032
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