Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator

The Bradyrhizobium japonicum transcriptional regulator Irr (iron response regulator) is a key regulator of the iron homeostasis, which is degraded in response to heme binding via a mechanism that involves oxidative modification of the protein. Here, we show that heme-bound Irr activates O(2) to form...

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Detalles Bibliográficos
Autores principales: Kitatsuji, Chihiro, Izumi, Kozue, Nambu, Shusuke, Kurogochi, Masaki, Uchida, Takeshi, Nishimura, Shin-Ichiro, Iwai, Kazuhiro, O’Brian, Mark R., Ikeda-Saito, Masao, Ishimori, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700492/
https://www.ncbi.nlm.nih.gov/pubmed/26729068
http://dx.doi.org/10.1038/srep18703

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