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Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics

INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) and midline high-grade glioma (mHGG) are lethal childhood brain tumors. Spatial genomic heterogeneity has been well-described in adult HGG but has not been comprehensively characterized in pediatric HGG. We performed whole exome sequencing on 38-...

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Detalles Bibliográficos
Autores principales:	Hoffman, Lindsey M., DeWire, Mariko, Ryall, Scott, Buczkowicz, Pawel, Leach, James, Miles, Lili, Ramani, Arun, Brudno, Michael, Kumar, Shiva Senthil, Drissi, Rachid, Dexheimer, Phillip, Salloum, Ralph, Chow, Lionel, Hummel, Trent, Stevenson, Charles, Lu, Q. Richard, Jones, Blaise, Witte, David, Aronow, Bruce, Hawkins, Cynthia E., Fouladi, Maryam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700584/ https://www.ncbi.nlm.nih.gov/pubmed/26727948 http://dx.doi.org/10.1186/s40478-015-0269-0

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