Spectrum of false positivity for the fourth generation human immunodeficiency virus diagnostic tests

Novel fourth generation screening and confirmatory human immunodeficiency virus (HIV) assays are now commercially available and incorporated into new diagnostic algorithms. We report two cases involving a total of three patients which highlight the spectrum of false positivity for both the Abbott Ar...

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Autores principales: Liu, Peter, Jackson, Patrick, Shaw, Nathan, Heysell, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700595/
https://www.ncbi.nlm.nih.gov/pubmed/26734067
http://dx.doi.org/10.1186/s12981-015-0086-3
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author Liu, Peter
Jackson, Patrick
Shaw, Nathan
Heysell, Scott
author_facet Liu, Peter
Jackson, Patrick
Shaw, Nathan
Heysell, Scott
author_sort Liu, Peter
collection PubMed
description Novel fourth generation screening and confirmatory human immunodeficiency virus (HIV) assays are now commercially available and incorporated into new diagnostic algorithms. We report two cases involving a total of three patients which highlight the spectrum of false positivity for both the Abbott Architect p24 antigen/antibody assay and the confirmatory Multispot antibody differentiation test. We then discuss the mechanisms for false positivity and the associated clinical conditions or laboratory scenarios that may predispose to inaccurate interpretation.
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spelling pubmed-47005952016-01-06 Spectrum of false positivity for the fourth generation human immunodeficiency virus diagnostic tests Liu, Peter Jackson, Patrick Shaw, Nathan Heysell, Scott AIDS Res Ther Case Report Novel fourth generation screening and confirmatory human immunodeficiency virus (HIV) assays are now commercially available and incorporated into new diagnostic algorithms. We report two cases involving a total of three patients which highlight the spectrum of false positivity for both the Abbott Architect p24 antigen/antibody assay and the confirmatory Multispot antibody differentiation test. We then discuss the mechanisms for false positivity and the associated clinical conditions or laboratory scenarios that may predispose to inaccurate interpretation. BioMed Central 2016-01-05 /pmc/articles/PMC4700595/ /pubmed/26734067 http://dx.doi.org/10.1186/s12981-015-0086-3 Text en © Liu et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Liu, Peter
Jackson, Patrick
Shaw, Nathan
Heysell, Scott
Spectrum of false positivity for the fourth generation human immunodeficiency virus diagnostic tests
title Spectrum of false positivity for the fourth generation human immunodeficiency virus diagnostic tests
title_full Spectrum of false positivity for the fourth generation human immunodeficiency virus diagnostic tests
title_fullStr Spectrum of false positivity for the fourth generation human immunodeficiency virus diagnostic tests
title_full_unstemmed Spectrum of false positivity for the fourth generation human immunodeficiency virus diagnostic tests
title_short Spectrum of false positivity for the fourth generation human immunodeficiency virus diagnostic tests
title_sort spectrum of false positivity for the fourth generation human immunodeficiency virus diagnostic tests
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700595/
https://www.ncbi.nlm.nih.gov/pubmed/26734067
http://dx.doi.org/10.1186/s12981-015-0086-3
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