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SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer

INTRODUCTION: Dysregulated receptor tyrosine kinase (RTK) signaling is a common occurrence in basal-like and triple-negative breast cancer (BTBC). As a result, RTK-targeting therapies have been initiated but proved difficult, mainly owing to the multiplicity of dysregulated RTKs. Hence, targeting ma...

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Detalles Bibliográficos
Autores principales:	Matalkah, Fatimah, Martin, Elisha, Zhao, Hua, Agazie, Yehenew M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700603/ https://www.ncbi.nlm.nih.gov/pubmed/26728598 http://dx.doi.org/10.1186/s13058-015-0659-z

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