Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock

We hypothesized that activated protein C does not increase in disseminated intravascular coagulation (DIC) after trauma and that the same is true for acute coagulopathy of trauma-shock (ACOTS). Activated protein C levels were prospectively measured in 57 trauma patients: 30 with DIC and 27 without D...

Descripción completa

Detalles Bibliográficos
Autores principales: Jesmin, Subrina, Gando, Satoshi, Wada, Takeshi, Hayakawa, Mineji, Sawamura, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700658/
https://www.ncbi.nlm.nih.gov/pubmed/26734467
http://dx.doi.org/10.1186/s40560-015-0123-2
_version_ 1782408358070845440
author Jesmin, Subrina
Gando, Satoshi
Wada, Takeshi
Hayakawa, Mineji
Sawamura, Atsushi
author_facet Jesmin, Subrina
Gando, Satoshi
Wada, Takeshi
Hayakawa, Mineji
Sawamura, Atsushi
author_sort Jesmin, Subrina
collection PubMed
description We hypothesized that activated protein C does not increase in disseminated intravascular coagulation (DIC) after trauma and that the same is true for acute coagulopathy of trauma-shock (ACOTS). Activated protein C levels were prospectively measured in 57 trauma patients: 30 with DIC and 27 without DIC. Normal to more decreased activated protein C levels were observed in DIC patients than in the controls and non-DIC patients. The activated protein C levels in ACOTS patients were similar to those in DIC patients. In conclusion, activated protein C does not increase in either DIC or ACOTS in the early phase of trauma.
format Online
Article
Text
id pubmed-4700658
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-47006582016-01-06 Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock Jesmin, Subrina Gando, Satoshi Wada, Takeshi Hayakawa, Mineji Sawamura, Atsushi J Intensive Care Letter to the Editor We hypothesized that activated protein C does not increase in disseminated intravascular coagulation (DIC) after trauma and that the same is true for acute coagulopathy of trauma-shock (ACOTS). Activated protein C levels were prospectively measured in 57 trauma patients: 30 with DIC and 27 without DIC. Normal to more decreased activated protein C levels were observed in DIC patients than in the controls and non-DIC patients. The activated protein C levels in ACOTS patients were similar to those in DIC patients. In conclusion, activated protein C does not increase in either DIC or ACOTS in the early phase of trauma. BioMed Central 2016-01-04 /pmc/articles/PMC4700658/ /pubmed/26734467 http://dx.doi.org/10.1186/s40560-015-0123-2 Text en © Jesmin et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Jesmin, Subrina
Gando, Satoshi
Wada, Takeshi
Hayakawa, Mineji
Sawamura, Atsushi
Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock
title Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock
title_full Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock
title_fullStr Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock
title_full_unstemmed Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock
title_short Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock
title_sort activated protein c does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700658/
https://www.ncbi.nlm.nih.gov/pubmed/26734467
http://dx.doi.org/10.1186/s40560-015-0123-2
work_keys_str_mv AT jesminsubrina activatedproteincdoesnotincreaseintheearlyphaseoftraumawithdisseminatedintravascularcoagulationcomparisonwithacutecoagulopathyoftraumashock
AT gandosatoshi activatedproteincdoesnotincreaseintheearlyphaseoftraumawithdisseminatedintravascularcoagulationcomparisonwithacutecoagulopathyoftraumashock
AT wadatakeshi activatedproteincdoesnotincreaseintheearlyphaseoftraumawithdisseminatedintravascularcoagulationcomparisonwithacutecoagulopathyoftraumashock
AT hayakawamineji activatedproteincdoesnotincreaseintheearlyphaseoftraumawithdisseminatedintravascularcoagulationcomparisonwithacutecoagulopathyoftraumashock
AT sawamuraatsushi activatedproteincdoesnotincreaseintheearlyphaseoftraumawithdisseminatedintravascularcoagulationcomparisonwithacutecoagulopathyoftraumashock

Ejemplares similares