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Chronic Activation of Heme Free Guanylate Cyclase Leads to Renal Protection in Dahl Salt-Sensitive Rats

The nitric oxide (NO)/soluble guanylate cyclase (sGC)/cyclic guanosine monophasphate (cGMP)-signalling pathway is impaired under oxidative stress conditions due to oxidation and subsequent loss of the prosthetic sGC heme group as observed in particular in chronic renal failure. Thus, the pool of hem...

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Detalles Bibliográficos
Autores principales:	Hoffmann, Linda S., Kretschmer, Axel, Lawrenz, Bettina, Hocher, Berthold, Stasch, Johannes-Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700984/ https://www.ncbi.nlm.nih.gov/pubmed/26717150 http://dx.doi.org/10.1371/journal.pone.0145048

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