Cargando…

A New Signaling Pathway for HCV Inhibition by Estrogen: GPR30 Activation Leads to Cleavage of Occludin by MMP-9

Poor outcome in response to hepatitis C virus, including higher viral load, hepatocellular carcinoma and cirrhosis, is more associated with men and postmenopausal women than with premenopausal women and women receiving hormone replacement therapy, suggesting that β-estradiol plays an innate role in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ulitzky, Laura, Lafer, Manuel M., KuKuruga, Mark A., Silberstein, Erica, Cehan, Nicoleta, Taylor, Deborah R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701175/ https://www.ncbi.nlm.nih.gov/pubmed/26731262 http://dx.doi.org/10.1371/journal.pone.0145212

Ejemplares similares

HCV-Mediated Apoptosis of Hepatocytes in Culture and Viral Pathogenesis
por: Silberstein, Erica, et al.
Publicado: (2016)

Neisseria meningitidis Induces Brain Microvascular Endothelial Cell Detachment from the Matrix and Cleavage of Occludin: A Role for MMP-8
por: Schubert-Unkmeir, Alexandra, et al.
Publicado: (2010)

G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health
por: Kim, Mi-Jin, et al.
Publicado: (2015)

Cleavage of Occludin by Cigarette Smoke-Elicited Cathepsin S Increases Permeability of Lung Epithelial Cells
por: Bigot, Paul, et al.
Publicado: (2022)

A relation between osteoclastogenesis inhibition and membrane-type estrogen receptor GPR30
por: Masuhara, Masaaki, et al.
Publicado: (2016)

Toll-like Receptor-9 (TLR-9) Signaling Is Crucial for Inducing Protective Immunity following Immunization with Genetically Modified Live Attenuated Leishmania Parasites
por: Bhattacharya, Parna, et al.
Publicado: (2023)

Reconsidering the roles of endogenous estrogens and xenoestrogens: the membrane estradiol receptor G protein-coupled receptor 30 (GPR30) mediates the effects of various estrogens
por: KADOKAWA, Hiroya, et al.
Publicado: (2018)

Interaction between GPR110 (ADGRF1) and tight junction protein occludin implicated in blood-brain barrier permeability
por: Huang, Bill X., et al.
Publicado: (2023)

Polymorphisms of estrogen receptors, ERα and GPR30: association with breast cancer susceptibility and prognosis
por: Alves, Susana M, et al.
Publicado: (2010)

Estrogen Regulates Hepcidin Expression via GPR30-BMP6-Dependent Signaling in Hepatocytes
por: Ikeda, Yasumasa, et al.
Publicado: (2012)

Enhanced expression of G-protein coupled estrogen receptor (GPER/GPR30) in lung cancer
por: Jala, Venkatakrishna Rao, et al.
Publicado: (2012)

The G-Protein-Coupled Estrogen Receptor (GPER/GPR30) in Ovarian Granulosa Cell Tumors
por: Heublein, Sabine, et al.
Publicado: (2014)

Roles of ERβ and GPR30 in Proliferative Response of Human Bladder Cancer Cell to Estrogen
por: Huang, Weiren, et al.
Publicado: (2015)

The Elk1/MMP-9 axis regulates E-cadherin and occludin in ventilator-induced lung injury
por: Tao, Zhao, et al.
Publicado: (2021)

GPR30, but not estrogen receptor-α, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol
por: Yates, Melissa A, et al.
Publicado: (2010)

Estrogen-Mediated Renoprotection following Cardiac Arrest and Cardiopulmonary Resuscitation Is Robust to GPR30 Gene Deletion
por: Hutchens, Michael P., et al.
Publicado: (2014)

Synergistic effect between LH and estrogen in the acceleration of cumulus expansion via GPR30 and EGFR pathways
por: Liu, Jie, et al.
Publicado: (2020)

The Cell Surface Estrogen Receptor, G Protein- Coupled Receptor 30 (GPR30), is Markedly Down Regulated During Breast Tumorigenesis
por: Poola, Indira, et al.
Publicado: (2008)

Claudin-6 and Occludin Natural Variants Found in a Patient Highly Exposed but Not Infected with Hepatitis C Virus (HCV) Do Not Confer HCV Resistance In Vitro
por: Fénéant, Lucie, et al.
Publicado: (2015)

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions
Publicado: (1994)

The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation
por: Zhang, Zengli, et al.
Publicado: (2018)

LPS Induces Occludin Dysregulation in Cerebral Microvascular Endothelial Cells via MAPK Signaling and Augmenting MMP-2 Levels
por: Qin, Lan-hui, et al.
Publicado: (2015)

The activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo
por: Wei, W, et al.
Publicado: (2014)

Early Exercise Protects the Blood-Brain Barrier from Ischemic Brain Injury via the Regulation of MMP-9 and Occludin in Rats
por: Zhang, Yuling, et al.
Publicado: (2013)

The G protein-coupled estrogen receptor 1 (GPER/GPR30) does not predict survival in patients with ovarian cancer
por: Kolkova, Zuzana, et al.
Publicado: (2012)

Genetic Variants of GPER/GPR30, a Novel Estrogen-Related G Protein Receptor, Are Associated with Human Seminoma
por: Chevalier, Nicolas, et al.
Publicado: (2014)

Estrogens Induce Rapid Cytoskeleton Re-Organization in Human Dermal Fibroblasts via the Non-Classical Receptor GPR30
por: Carnesecchi, Julie, et al.
Publicado: (2015)

Endocytosis takes occludin for a ride
por: Leslie, Mitch
Publicado: (2010)

Low Expression of Occludin in the Melanoma Patient
por: Salehi, Pouri, et al.
Publicado: (2019)

The positivity of G-protein-coupled receptor-30 (GPR 30), an alternative estrogen receptor is not different between type 1 and type 2 endometrial cancer
por: Wan, Jiayi, et al.
Publicado: (2017)

Exploring the Potential Use of a PBMC-Based Functional Assay to Identify Predictive Biomarkers for Anti-PD-1 Immunotherapy
por: Bacot, Silvia M., et al.
Publicado: (2020)

In vivo Effects of a GPR30 Antagonist
por: Dennis, Megan K., et al.
Publicado: (2009)

Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA
por: Harrer, Aileen, et al.
Publicado: (2019)

Effects of estrogen receptor GPR30 agonist G1 on neuronal apoptosis and microglia polarization in traumatic brain injury rats
por: Pan, Meng-Xian, et al.
Publicado: (2018)

Estrogen/GPR30 Signaling Contributes to the Malignant Potentials of ER-Negative Cervical Adenocarcinoma via Regulation of Claudin-1 Expression
por: Akimoto, Taishi, et al.
Publicado: (2018)

Expression and Role of the G Protein-Coupled Estrogen Receptor (GPR30/GPER) in the Development and Immune Response in Female Reproductive Cancers
por: Hernández-Silva, Christian David, et al.
Publicado: (2020)

GPR30-mediated non-classic estrogen pathway in mast cells participates in endometriosis pain via the production of FGF2
por: Xu, Xinxin, et al.
Publicado: (2023)

Connexin-Occludin Chimeras Containing the Zo-Binding Domain of Occludin Localize at Mdck Tight Junctions and Nrk Cell Contacts
por: Mitic, Laura L., et al.
Publicado: (1999)

Occludin is overexpressed in Alzheimer's disease and vascular dementia
por: Romanitan, Mihaela Oana, et al.
Publicado: (2007)

GPR30, the Non-Classical Membrane G Protein Related Estrogen Receptor, Is Overexpressed in Human Seminoma and Promotes Seminoma Cell Proliferation
por: Chevalier, Nicolas, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ojtfpstd1o2lmnpmk5002u13ei