MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation

Conventional high-grade osteosarcoma is the most common primary bone cancer with relatively high incidence in young people. Recurrent and metastatic tumors are difficult to treat. We performed a kinase inhibitor screen in two osteosarcoma cell lines, which identified MEK1/2 inhibitors. These inhibit...

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Detalles Bibliográficos
Autores principales: Baranski, Zuzanna, Booij, Tijmen H., Kuijjer, Marieke L., de Jong, Yvonne, Cleton-Jansen, Anne-Marie, Price, Leo S., van de Water, Bob, Bovée, Judith V. M. G., Hogendoorn, Pancras C.W., Danen, Erik H.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701229/
https://www.ncbi.nlm.nih.gov/pubmed/26807203

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