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Correlations of Metabolic Components with Prostate Volume in Middle-Aged Men Receiving Health Check-Up
OBJECTIVES: To investigate the impact of metabolic components and body composition indices on prostate volume (PV) in a population of middle-aged men receiving health check-ups. METHODS: Six hundred and sixteen men receiving health assessments were stratified to large and small prostates based on th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701412/ https://www.ncbi.nlm.nih.gov/pubmed/26731481 http://dx.doi.org/10.1371/journal.pone.0145050 |
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author | Yang, Teng-Kai Woo, Peter Yang, Hung-Ju Chang, Hong-Chiang Hsieh, Ju-Ton Huang, Kuo-How |
author_facet | Yang, Teng-Kai Woo, Peter Yang, Hung-Ju Chang, Hong-Chiang Hsieh, Ju-Ton Huang, Kuo-How |
author_sort | Yang, Teng-Kai |
collection | PubMed |
description | OBJECTIVES: To investigate the impact of metabolic components and body composition indices on prostate volume (PV) in a population of middle-aged men receiving health check-ups. METHODS: Six hundred and sixteen men receiving health assessments were stratified to large and small prostates based on the cut-off of median PV. Their demographic data, health history, and international prostate symptoms scores (IPSS) were collected. Metabolic components and body composition indices were compared between subjects with large and small prostates. Moreover, the correlations between these parameters and PV were analyzed by multivariate logistic regression. RESULTS: The median PV was 27 mL and mean age was 54.8 years. Subjects with large PV were older (56.5 vs. 52.7 years) and had higher serum prostate specific antigen (PSA) level (1.73 vs. 0.96 ng/mL), higher IPSS score (8.37 vs. 6.16), and higher body fat, body mass, and waist circumference (all p<0.05). In multivariate analysis, age (OR, 2.45; 95%CI, 1.74–3.45), serum PSA (OR, 2.75; 95%CI, 1.96–3.86), waist circumference (OR, 1.45; 95%CI, 1.02–2.07), fatness (OR, 1.47; 95%CI, 1.04–2.09), and body fat mass (OR, 1.43; 95%CI, 1.00–2.03) were significantly correlated with PV of study subjects. In subgroup analysis, raised waist circumference (OR, 1.89; 95%CI, 1.00–3.59) was the independent predictor of PV in subjects with bothersome lower urinary tract symptoms. CONCLUSIONS: Several metabolic components and body composition indices are significantly associated with PV of middle-aged men, including raised waist circumference, fatness, and body fat mass. Raised waist circumference is the only independent predictor of PV in middle-aged men with bothersome LUTS. |
format | Online Article Text |
id | pubmed-4701412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47014122016-01-15 Correlations of Metabolic Components with Prostate Volume in Middle-Aged Men Receiving Health Check-Up Yang, Teng-Kai Woo, Peter Yang, Hung-Ju Chang, Hong-Chiang Hsieh, Ju-Ton Huang, Kuo-How PLoS One Research Article OBJECTIVES: To investigate the impact of metabolic components and body composition indices on prostate volume (PV) in a population of middle-aged men receiving health check-ups. METHODS: Six hundred and sixteen men receiving health assessments were stratified to large and small prostates based on the cut-off of median PV. Their demographic data, health history, and international prostate symptoms scores (IPSS) were collected. Metabolic components and body composition indices were compared between subjects with large and small prostates. Moreover, the correlations between these parameters and PV were analyzed by multivariate logistic regression. RESULTS: The median PV was 27 mL and mean age was 54.8 years. Subjects with large PV were older (56.5 vs. 52.7 years) and had higher serum prostate specific antigen (PSA) level (1.73 vs. 0.96 ng/mL), higher IPSS score (8.37 vs. 6.16), and higher body fat, body mass, and waist circumference (all p<0.05). In multivariate analysis, age (OR, 2.45; 95%CI, 1.74–3.45), serum PSA (OR, 2.75; 95%CI, 1.96–3.86), waist circumference (OR, 1.45; 95%CI, 1.02–2.07), fatness (OR, 1.47; 95%CI, 1.04–2.09), and body fat mass (OR, 1.43; 95%CI, 1.00–2.03) were significantly correlated with PV of study subjects. In subgroup analysis, raised waist circumference (OR, 1.89; 95%CI, 1.00–3.59) was the independent predictor of PV in subjects with bothersome lower urinary tract symptoms. CONCLUSIONS: Several metabolic components and body composition indices are significantly associated with PV of middle-aged men, including raised waist circumference, fatness, and body fat mass. Raised waist circumference is the only independent predictor of PV in middle-aged men with bothersome LUTS. Public Library of Science 2016-01-05 /pmc/articles/PMC4701412/ /pubmed/26731481 http://dx.doi.org/10.1371/journal.pone.0145050 Text en © 2016 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
spellingShingle | Research Article Yang, Teng-Kai Woo, Peter Yang, Hung-Ju Chang, Hong-Chiang Hsieh, Ju-Ton Huang, Kuo-How Correlations of Metabolic Components with Prostate Volume in Middle-Aged Men Receiving Health Check-Up |
title | Correlations of Metabolic Components with Prostate Volume in Middle-Aged Men Receiving Health Check-Up |
title_full | Correlations of Metabolic Components with Prostate Volume in Middle-Aged Men Receiving Health Check-Up |
title_fullStr | Correlations of Metabolic Components with Prostate Volume in Middle-Aged Men Receiving Health Check-Up |
title_full_unstemmed | Correlations of Metabolic Components with Prostate Volume in Middle-Aged Men Receiving Health Check-Up |
title_short | Correlations of Metabolic Components with Prostate Volume in Middle-Aged Men Receiving Health Check-Up |
title_sort | correlations of metabolic components with prostate volume in middle-aged men receiving health check-up |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701412/ https://www.ncbi.nlm.nih.gov/pubmed/26731481 http://dx.doi.org/10.1371/journal.pone.0145050 |
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