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Interplay between Subthreshold Oscillations and Depressing Synapses in Single Neurons
In this paper we analyze the interplay between the subthreshold oscillations of a single neuron conductance-based model and the short-term plasticity of a dynamic synapse with a depressing mechanism. In previous research, the computational properties of subthreshold oscillations and dynamic synapses...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701431/ https://www.ncbi.nlm.nih.gov/pubmed/26730737 http://dx.doi.org/10.1371/journal.pone.0145830 |
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author | Latorre, Roberto Torres, Joaquín J. Varona, Pablo |
author_facet | Latorre, Roberto Torres, Joaquín J. Varona, Pablo |
author_sort | Latorre, Roberto |
collection | PubMed |
description | In this paper we analyze the interplay between the subthreshold oscillations of a single neuron conductance-based model and the short-term plasticity of a dynamic synapse with a depressing mechanism. In previous research, the computational properties of subthreshold oscillations and dynamic synapses have been studied separately. Our results show that dynamic synapses can influence different aspects of the dynamics of neuronal subthreshold oscillations. Factors such as maximum hyperpolarization level, oscillation amplitude and frequency or the resulting firing threshold are modulated by synaptic depression, which can even make subthreshold oscillations disappear. This influence reshapes the postsynaptic neuron’s resonant properties arising from subthreshold oscillations and leads to specific input/output relations. We also study the neuron’s response to another simultaneous input in the context of this modulation, and show a distinct contextual processing as a function of the depression, in particular for detection of signals through weak synapses. Intrinsic oscillations dynamics can be combined with the characteristic time scale of the modulatory input received by a dynamic synapse to build cost-effective cell/channel-specific information discrimination mechanisms, beyond simple resonances. In this regard, we discuss the functional implications of synaptic depression modulation on intrinsic subthreshold dynamics. |
format | Online Article Text |
id | pubmed-4701431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47014312016-01-15 Interplay between Subthreshold Oscillations and Depressing Synapses in Single Neurons Latorre, Roberto Torres, Joaquín J. Varona, Pablo PLoS One Research Article In this paper we analyze the interplay between the subthreshold oscillations of a single neuron conductance-based model and the short-term plasticity of a dynamic synapse with a depressing mechanism. In previous research, the computational properties of subthreshold oscillations and dynamic synapses have been studied separately. Our results show that dynamic synapses can influence different aspects of the dynamics of neuronal subthreshold oscillations. Factors such as maximum hyperpolarization level, oscillation amplitude and frequency or the resulting firing threshold are modulated by synaptic depression, which can even make subthreshold oscillations disappear. This influence reshapes the postsynaptic neuron’s resonant properties arising from subthreshold oscillations and leads to specific input/output relations. We also study the neuron’s response to another simultaneous input in the context of this modulation, and show a distinct contextual processing as a function of the depression, in particular for detection of signals through weak synapses. Intrinsic oscillations dynamics can be combined with the characteristic time scale of the modulatory input received by a dynamic synapse to build cost-effective cell/channel-specific information discrimination mechanisms, beyond simple resonances. In this regard, we discuss the functional implications of synaptic depression modulation on intrinsic subthreshold dynamics. Public Library of Science 2016-01-05 /pmc/articles/PMC4701431/ /pubmed/26730737 http://dx.doi.org/10.1371/journal.pone.0145830 Text en © 2016 Latorre et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
spellingShingle | Research Article Latorre, Roberto Torres, Joaquín J. Varona, Pablo Interplay between Subthreshold Oscillations and Depressing Synapses in Single Neurons |
title | Interplay between Subthreshold Oscillations and Depressing Synapses in Single Neurons |
title_full | Interplay between Subthreshold Oscillations and Depressing Synapses in Single Neurons |
title_fullStr | Interplay between Subthreshold Oscillations and Depressing Synapses in Single Neurons |
title_full_unstemmed | Interplay between Subthreshold Oscillations and Depressing Synapses in Single Neurons |
title_short | Interplay between Subthreshold Oscillations and Depressing Synapses in Single Neurons |
title_sort | interplay between subthreshold oscillations and depressing synapses in single neurons |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701431/ https://www.ncbi.nlm.nih.gov/pubmed/26730737 http://dx.doi.org/10.1371/journal.pone.0145830 |
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