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Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis
BACKGROUND: Reduced white matter (WM) integrity is a fundamental aspect of pediatric multiple sclerosis (MS), though relations to resting-state functional MRI (fMRI) connectivity remain unknown. The objective of this study was to relate diffusion-tensor imaging (DTI) measures of WM microstructural i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701472/ https://www.ncbi.nlm.nih.gov/pubmed/26731278 http://dx.doi.org/10.1371/journal.pone.0145906 |
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author | Akbar, Nadine Giorgio, Antonio Till, Christine Sled, John G. Doesburg, Sam M. De Stefano, Nicola Banwell, Brenda |
author_facet | Akbar, Nadine Giorgio, Antonio Till, Christine Sled, John G. Doesburg, Sam M. De Stefano, Nicola Banwell, Brenda |
author_sort | Akbar, Nadine |
collection | PubMed |
description | BACKGROUND: Reduced white matter (WM) integrity is a fundamental aspect of pediatric multiple sclerosis (MS), though relations to resting-state functional MRI (fMRI) connectivity remain unknown. The objective of this study was to relate diffusion-tensor imaging (DTI) measures of WM microstructural integrity to resting-state network (RSN) functional connectivity in pediatric-onset MS to test the hypothesis that abnormalities in RSN reflects changes in structural integrity. METHODS: This study enrolled 19 patients with pediatric-onset MS (mean age = 19, range 13–24 years, 14 female, mean disease duration = 65 months, mean age of disease onset = 13 years) and 16 age- and sex-matched healthy controls (HC). All subjects underwent 3.0T anatomical and functional MRI which included DTI and resting-state acquisitions. DTI processing was performed using Tract-Based Spatial Statistics (TBSS). RSNs were identified using Independent Components Analysis, and a dual regression technique was used to detect between-group differences in the functional connectivity of RSNs. Correlations were investigated between DTI measures and RSN connectivity. RESULTS: Lower fractional anisotropy (FA) was observed in the pediatric-onset MS group compared to HC group within the entire WM skeleton, and particularly the corpus callosum, posterior thalamic radiation, corona radiata and sagittal stratum (all p < .01, corrected). Relative to HCs, MS patients showed higher functional connectivity involving the anterior cingulate cortex and right precuneus of the default-mode network, as well as involving the anterior cingulate cortex and left middle frontal gyrus of the frontoparietal network (all p < .005 uncorrected, k≥30 voxels). Higher functional connectivity of the right precuneus within the default-mode network was associated with lower FA of the entire WM skeleton (r = -.525, p = .02), genu of the corpus callosum (r = -.553, p = .014), and left (r = -.467, p = .044) and right (r = -.615, p = .005) sagittal stratum. CONCLUSIONS: Loss of WM microstructural integrity is associated with increased resting-state functional connectivity in pediatric MS, which may reflect a diffuse and potentially compensatory activation early in MS. |
format | Online Article Text |
id | pubmed-4701472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47014722016-01-15 Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis Akbar, Nadine Giorgio, Antonio Till, Christine Sled, John G. Doesburg, Sam M. De Stefano, Nicola Banwell, Brenda PLoS One Research Article BACKGROUND: Reduced white matter (WM) integrity is a fundamental aspect of pediatric multiple sclerosis (MS), though relations to resting-state functional MRI (fMRI) connectivity remain unknown. The objective of this study was to relate diffusion-tensor imaging (DTI) measures of WM microstructural integrity to resting-state network (RSN) functional connectivity in pediatric-onset MS to test the hypothesis that abnormalities in RSN reflects changes in structural integrity. METHODS: This study enrolled 19 patients with pediatric-onset MS (mean age = 19, range 13–24 years, 14 female, mean disease duration = 65 months, mean age of disease onset = 13 years) and 16 age- and sex-matched healthy controls (HC). All subjects underwent 3.0T anatomical and functional MRI which included DTI and resting-state acquisitions. DTI processing was performed using Tract-Based Spatial Statistics (TBSS). RSNs were identified using Independent Components Analysis, and a dual regression technique was used to detect between-group differences in the functional connectivity of RSNs. Correlations were investigated between DTI measures and RSN connectivity. RESULTS: Lower fractional anisotropy (FA) was observed in the pediatric-onset MS group compared to HC group within the entire WM skeleton, and particularly the corpus callosum, posterior thalamic radiation, corona radiata and sagittal stratum (all p < .01, corrected). Relative to HCs, MS patients showed higher functional connectivity involving the anterior cingulate cortex and right precuneus of the default-mode network, as well as involving the anterior cingulate cortex and left middle frontal gyrus of the frontoparietal network (all p < .005 uncorrected, k≥30 voxels). Higher functional connectivity of the right precuneus within the default-mode network was associated with lower FA of the entire WM skeleton (r = -.525, p = .02), genu of the corpus callosum (r = -.553, p = .014), and left (r = -.467, p = .044) and right (r = -.615, p = .005) sagittal stratum. CONCLUSIONS: Loss of WM microstructural integrity is associated with increased resting-state functional connectivity in pediatric MS, which may reflect a diffuse and potentially compensatory activation early in MS. Public Library of Science 2016-01-05 /pmc/articles/PMC4701472/ /pubmed/26731278 http://dx.doi.org/10.1371/journal.pone.0145906 Text en © 2016 Akbar et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
spellingShingle | Research Article Akbar, Nadine Giorgio, Antonio Till, Christine Sled, John G. Doesburg, Sam M. De Stefano, Nicola Banwell, Brenda Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis |
title | Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis |
title_full | Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis |
title_fullStr | Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis |
title_full_unstemmed | Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis |
title_short | Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis |
title_sort | alterations in functional and structural connectivity in pediatric-onset multiple sclerosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701472/ https://www.ncbi.nlm.nih.gov/pubmed/26731278 http://dx.doi.org/10.1371/journal.pone.0145906 |
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