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Disconnect Between Adipose Tissue Inflammation and Cardiometabolic Dysfunction in Ossabaw Pigs
OBJECTIVE: The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease due to its size and susceptibility to atherosclerosis, among other characteristics. Here we investigated the relationship between adipose tissue inflammation and metabolic dysfunction in this model. METHOD...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701582/ https://www.ncbi.nlm.nih.gov/pubmed/26524201 http://dx.doi.org/10.1002/oby.21252 |
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author | Vieira-Potter, Victoria J. Lee, Sewon Bayless, David S. Scroggins, Rebecca J. Welly, Rebecca J. Fleming, Nicholas J. Smith, Thomas N. Meers, Grace M. Hill, Michael A. Rector, R. Scott Padilla, Jaume |
author_facet | Vieira-Potter, Victoria J. Lee, Sewon Bayless, David S. Scroggins, Rebecca J. Welly, Rebecca J. Fleming, Nicholas J. Smith, Thomas N. Meers, Grace M. Hill, Michael A. Rector, R. Scott Padilla, Jaume |
author_sort | Vieira-Potter, Victoria J. |
collection | PubMed |
description | OBJECTIVE: The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease due to its size and susceptibility to atherosclerosis, among other characteristics. Here we investigated the relationship between adipose tissue inflammation and metabolic dysfunction in this model. METHODS: Young female Ossabaw pigs were fed a western-style high-fat diet (HFD) (n=4) or control low-fat diet (LFD) (n=4) for a period of 9 months and compared for cardiometabolic outcomes and adipose tissue inflammation. RESULTS: The HFD-fed “OBESE” pigs were 2.5 times heavier (p<0.001) than LFD-fed “LEAN” pigs and developed severe obesity. HFD-feeding caused pronounced dyslipidemia, hypertension, insulin resistance (systemic and adipose) as well as induction of inflammatory genes, impairments in vasomotor reactivity to insulin and atherosclerosis in the coronary arteries. Remarkably, visceral, subcutaneous and perivascular adipose tissue inflammation (via FACS analysis and RT-PCR) was not increased in OBESE pigs, nor were circulating inflammatory cytokines. CONCLUSIONS: These findings reveal a disconnect between adipose tissue inflammation and cardiometabolic dysfunction induced by western diet feeding in the Ossabaw pig model. |
format | Online Article Text |
id | pubmed-4701582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-47015822016-05-18 Disconnect Between Adipose Tissue Inflammation and Cardiometabolic Dysfunction in Ossabaw Pigs Vieira-Potter, Victoria J. Lee, Sewon Bayless, David S. Scroggins, Rebecca J. Welly, Rebecca J. Fleming, Nicholas J. Smith, Thomas N. Meers, Grace M. Hill, Michael A. Rector, R. Scott Padilla, Jaume Obesity (Silver Spring) Article OBJECTIVE: The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease due to its size and susceptibility to atherosclerosis, among other characteristics. Here we investigated the relationship between adipose tissue inflammation and metabolic dysfunction in this model. METHODS: Young female Ossabaw pigs were fed a western-style high-fat diet (HFD) (n=4) or control low-fat diet (LFD) (n=4) for a period of 9 months and compared for cardiometabolic outcomes and adipose tissue inflammation. RESULTS: The HFD-fed “OBESE” pigs were 2.5 times heavier (p<0.001) than LFD-fed “LEAN” pigs and developed severe obesity. HFD-feeding caused pronounced dyslipidemia, hypertension, insulin resistance (systemic and adipose) as well as induction of inflammatory genes, impairments in vasomotor reactivity to insulin and atherosclerosis in the coronary arteries. Remarkably, visceral, subcutaneous and perivascular adipose tissue inflammation (via FACS analysis and RT-PCR) was not increased in OBESE pigs, nor were circulating inflammatory cytokines. CONCLUSIONS: These findings reveal a disconnect between adipose tissue inflammation and cardiometabolic dysfunction induced by western diet feeding in the Ossabaw pig model. 2015-11-02 2015-12 /pmc/articles/PMC4701582/ /pubmed/26524201 http://dx.doi.org/10.1002/oby.21252 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Vieira-Potter, Victoria J. Lee, Sewon Bayless, David S. Scroggins, Rebecca J. Welly, Rebecca J. Fleming, Nicholas J. Smith, Thomas N. Meers, Grace M. Hill, Michael A. Rector, R. Scott Padilla, Jaume Disconnect Between Adipose Tissue Inflammation and Cardiometabolic Dysfunction in Ossabaw Pigs |
title | Disconnect Between Adipose Tissue Inflammation and Cardiometabolic Dysfunction in Ossabaw Pigs |
title_full | Disconnect Between Adipose Tissue Inflammation and Cardiometabolic Dysfunction in Ossabaw Pigs |
title_fullStr | Disconnect Between Adipose Tissue Inflammation and Cardiometabolic Dysfunction in Ossabaw Pigs |
title_full_unstemmed | Disconnect Between Adipose Tissue Inflammation and Cardiometabolic Dysfunction in Ossabaw Pigs |
title_short | Disconnect Between Adipose Tissue Inflammation and Cardiometabolic Dysfunction in Ossabaw Pigs |
title_sort | disconnect between adipose tissue inflammation and cardiometabolic dysfunction in ossabaw pigs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701582/ https://www.ncbi.nlm.nih.gov/pubmed/26524201 http://dx.doi.org/10.1002/oby.21252 |
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