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Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man

CONTEXT: 5α-Reductase 1 and 2 (SRD5A1, SRD5A2) inactivate cortisol to 5α-dihydrocortisol in addition to their role in the generation of DHT. Dutasteride (dual SRD5A1 and SRD5A2 inhibitor) and finasteride (selective SRD5A2 inhibitor) are commonly prescribed, but their potential metabolic effects have...

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Detalles Bibliográficos
Autores principales:	Hazlehurst, Jonathan M., Oprescu, Andrei I., Nikolaou, Nikolaos, Di Guida, Riccardo, Grinbergs, Annabel E. K., Davies, Nigel P., Flintham, Robert B., Armstrong, Matthew J., Taylor, Angela E., Hughes, Beverly A., Yu, Jinglei, Hodson, Leanne, Dunn, Warwick B., Tomlinson, Jeremy W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701851/ https://www.ncbi.nlm.nih.gov/pubmed/26574953 http://dx.doi.org/10.1210/jc.2015-2928

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