Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a

Unlike clustered HOX genes, the role of nonclustered homeobox gene family members in hematopoiesis and leukemogenesis has not been extensively studied. Here we found that the hematopoietically expressed homeobox gene Hhex is overexpressed in acute myeloid leukemia (AML) and is essential for the init...

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Detalles Bibliográficos
Autores principales: Shields, Benjamin J., Jackson, Jacob T., Metcalf, Donald, Shi, Wei, Huang, Qiutong, Garnham, Alexandra L., Glaser, Stefan P., Beck, Dominik, Pimanda, John E., Bogue, Clifford W., Smyth, Gordon K., Alexander, Warren S., McCormack, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701980/
https://www.ncbi.nlm.nih.gov/pubmed/26728554
http://dx.doi.org/10.1101/gad.268425.115

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