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Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma

BACKGROUND: The cyclin-dependent kinase inhibitor 3 (CDKN3) has been perceived as a tumour suppressor. Paradoxically, CDKN3 is often overexpressed in human cancer. It was unclear if CDKN3 overexpression is linked to alternative splicing variants or mutations that produce dominant-negative CDKN3. MET...

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Detalles Bibliográficos
Autores principales:	Fan, Chao, Chen, Lu, Huang, Qingling, Shen, Tao, Welsh, Eric A, Teer, Jamie K, Cai, Jianfeng, Cress, W Douglas, Wu, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Genetics & Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701993/ https://www.ncbi.nlm.nih.gov/pubmed/26554648 http://dx.doi.org/10.1038/bjc.2015.378

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