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Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options

Research in immunology has brought great progress in knowledge of inflammatory processes in the last 2 decades, which also has an impact on the upper airways. Our understanding of the pathophysiology of chronic rhinosinusitis developed from a rather mechanistic point of view with a focus on narrow c...

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Detalles Bibliográficos
Autores principales: Bachert, Claus, Holtappels, Gabriële
Formato: Online Artículo Texto
Lenguaje:English
Publicado: German Medical Science GMS Publishing House 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702058/
https://www.ncbi.nlm.nih.gov/pubmed/26770283
http://dx.doi.org/10.3205/cto000124
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author Bachert, Claus
Holtappels, Gabriële
author_facet Bachert, Claus
Holtappels, Gabriële
author_sort Bachert, Claus
collection PubMed
description Research in immunology has brought great progress in knowledge of inflammatory processes in the last 2 decades, which also has an impact on the upper airways. Our understanding of the pathophysiology of chronic rhinosinusitis developed from a rather mechanistic point of view with a focus on narrow clefts and mucociliary clearance to the appreciation of a complex network of immunological pathways forming the basis of disease. We today differentiate various forms of inflammation, we start to understand complex immune-regulatory networks and the reasons for their failure, and have already developed innovative approaches for therapy for the most severely ill subjects. Due to this new knowledge in inflammation and remodeling processes within mucosal tissue, specifically on the key driving factors, new diagnostic tools and therapeutic approaches for chronic rhinosinusitis have developed; the differentiation of endotypes based on pathophysiological principles will be crucial for the use of innovative therapies, mostly humanized monoclonal antibodies. Several hundred of those antibodies are currently developed for various indications and will impact our specialty as well as pneumology to a great extent.
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spelling pubmed-47020582016-01-14 Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options Bachert, Claus Holtappels, Gabriële GMS Curr Top Otorhinolaryngol Head Neck Surg Article Research in immunology has brought great progress in knowledge of inflammatory processes in the last 2 decades, which also has an impact on the upper airways. Our understanding of the pathophysiology of chronic rhinosinusitis developed from a rather mechanistic point of view with a focus on narrow clefts and mucociliary clearance to the appreciation of a complex network of immunological pathways forming the basis of disease. We today differentiate various forms of inflammation, we start to understand complex immune-regulatory networks and the reasons for their failure, and have already developed innovative approaches for therapy for the most severely ill subjects. Due to this new knowledge in inflammation and remodeling processes within mucosal tissue, specifically on the key driving factors, new diagnostic tools and therapeutic approaches for chronic rhinosinusitis have developed; the differentiation of endotypes based on pathophysiological principles will be crucial for the use of innovative therapies, mostly humanized monoclonal antibodies. Several hundred of those antibodies are currently developed for various indications and will impact our specialty as well as pneumology to a great extent. German Medical Science GMS Publishing House 2015-12-22 /pmc/articles/PMC4702058/ /pubmed/26770283 http://dx.doi.org/10.3205/cto000124 Text en Copyright © 2015 Bachert et al. http://creativecommons.org/licenses/by-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Share Alike 4.0 License.
spellingShingle Article
Bachert, Claus
Holtappels, Gabriële
Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options
title Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options
title_full Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options
title_fullStr Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options
title_full_unstemmed Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options
title_short Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options
title_sort pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702058/
https://www.ncbi.nlm.nih.gov/pubmed/26770283
http://dx.doi.org/10.3205/cto000124
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