Embelin binds to human neuroserpin and impairs its polymerisation

Neuroserpin (NS) is a serpin inhibitor of tissue plasminogen activator (tPA) in the brain. The polymerisation of NS pathologic mutants is responsible for a genetic dementia known as familial encephalopathy with neuroserpin inclusion bodies (FENIB). So far, a pharmacological treatment of FENIB, i.e....

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Detalles Bibliográficos
Autores principales: Saga, Giorgia, Sessa, Fabio, Barbiroli, Alberto, Santambrogio, Carlo, Russo, Rosaria, Sala, Michela, Raccosta, Samuele, Martorana, Vincenzo, Caccia, Sonia, Noto, Rosina, Moriconi, Claudia, Miranda, Elena, Grandori, Rita, Manno, Mauro, Bolognesi, Martino, Ricagno, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702122/
https://www.ncbi.nlm.nih.gov/pubmed/26732982
http://dx.doi.org/10.1038/srep18769

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