Discovering new mTOR inhibitors for cancer treatment through virtual screening methods and in vitro assays

Mammalian target of rapamycin (mTOR) is an attractive target for new anticancer drug development. We recently developed in silico models to distinguish mTOR inhibitors and non-inhibitors. In this study, we developed an integrated strategy for identifying new mTOR inhibitors using cascaded in silico...

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Detalles Bibliográficos
Autores principales: Wang, Ling, Chen, Lei, Yu, Miao, Xu, Li-Hui, Cheng, Bao, Lin, Yong-Sheng, Gu, Qiong, He, Xian-Hui, Xu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702177/
https://www.ncbi.nlm.nih.gov/pubmed/26732172
http://dx.doi.org/10.1038/srep18987

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