Insulin-like growth factor 1 receptor expression and IGF1R 3129G > T polymorphism are associated with response to neoadjuvant chemotherapy in breast cancer patients: results from the NEOZOTAC trial (BOOG 2010-01)

BACKGROUND: The insulin-like growth factor 1 (IGF-1) pathway is involved in cell growth and proliferation and is associated with tumorigenesis and therapy resistance. This study aims to elucidate whether variation in the IGF-1 pathway is predictive for pathologic response in early HER2 negative brea...

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Detalles Bibliográficos
Autores principales: de Groot, Stefanie, Charehbili, Ayoub, van Laarhoven, Hanneke W. M., Mooyaart, Antien L., Dekker-Ensink, N. Geeske, van de Ven, Saskia, Janssen, Laura G. M., Swen, Jesse J., Smit, Vincent T. H. B. M., Heijns, Joan B., Kessels, Lonneke W., van der Straaten, Tahar, Böhringer, Stefan, Gelderblom, Hans, van der Hoeven, Jacobus J. M., Guchelaar, Henk-Jan, Pijl, Hanno, Kroep, Judith R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702399/
https://www.ncbi.nlm.nih.gov/pubmed/26738606
http://dx.doi.org/10.1186/s13058-015-0663-3

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