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TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling

Host restriction factor TRIM5 inhibits retroviral transduction in a species-specific manner by binding to and destabilizing the retroviral capsid lattice before reverse transcription is completed. However, the restriction mechanism may not be that simple since TRIM5 E3 ubiquitin ligase activity, the...

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Detalles Bibliográficos
Autores principales:	Lascano, Josefina, Uchil, Pradeep D., Mothes, Walther, Luban, Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2015
Materias:	Virus-Cell Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702541/ https://www.ncbi.nlm.nih.gov/pubmed/26468522 http://dx.doi.org/10.1128/JVI.02496-15

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