Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance

In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST)....

Descripción completa

Detalles Bibliográficos
Autores principales: Kirwan, Daniela E., Ugarte-Gil, Cesar, Gilman, Robert H., Caviedes, Luz, Rizvi, Hasan, Ticona, Eduardo, Chavez, Gonzalo, Cabrera, José Luis, Matos, Eduardo D., Evans, Carlton A., Moore, David A. J., Friedland, Jon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Mycobacteriology and Aerobic Actinomycetes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702711/
https://www.ncbi.nlm.nih.gov/pubmed/26511739
http://dx.doi.org/10.1128/JCM.02227-15
_version_ 1782408644927684608
author Kirwan, Daniela E.
Ugarte-Gil, Cesar
Gilman, Robert H.
Caviedes, Luz
Rizvi, Hasan
Ticona, Eduardo
Chavez, Gonzalo
Cabrera, José Luis
Matos, Eduardo D.
Evans, Carlton A.
Moore, David A. J.
Friedland, Jon S.
author_facet Kirwan, Daniela E.
Ugarte-Gil, Cesar
Gilman, Robert H.
Caviedes, Luz
Rizvi, Hasan
Ticona, Eduardo
Chavez, Gonzalo
Cabrera, José Luis
Matos, Eduardo D.
Evans, Carlton A.
Moore, David A. J.
Friedland, Jon S.
author_sort Kirwan, Daniela E.
collection PubMed
description In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.
format Online
Article
Text
id pubmed-4702711
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-47027112016-02-11 Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance Kirwan, Daniela E. Ugarte-Gil, Cesar Gilman, Robert H. Caviedes, Luz Rizvi, Hasan Ticona, Eduardo Chavez, Gonzalo Cabrera, José Luis Matos, Eduardo D. Evans, Carlton A. Moore, David A. J. Friedland, Jon S. J Clin Microbiol Mycobacteriology and Aerobic Actinomycetes In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB. American Society for Microbiology 2016-01 2015-12-30 /pmc/articles/PMC4702711/ /pubmed/26511739 http://dx.doi.org/10.1128/JCM.02227-15 Text en Copyright © 2015 Kirwan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Mycobacteriology and Aerobic Actinomycetes
Kirwan, Daniela E.
Ugarte-Gil, Cesar
Gilman, Robert H.
Caviedes, Luz
Rizvi, Hasan
Ticona, Eduardo
Chavez, Gonzalo
Cabrera, José Luis
Matos, Eduardo D.
Evans, Carlton A.
Moore, David A. J.
Friedland, Jon S.
Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance
title Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance
title_full Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance
title_fullStr Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance
title_full_unstemmed Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance
title_short Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance
title_sort microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance
topic Mycobacteriology and Aerobic Actinomycetes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702711/
https://www.ncbi.nlm.nih.gov/pubmed/26511739
http://dx.doi.org/10.1128/JCM.02227-15
work_keys_str_mv AT kirwandanielae microscopicobservationdrugsusceptibilityassayforrapiddiagnosisoflymphnodetuberculosisanddetectionofdrugresistance
AT ugartegilcesar microscopicobservationdrugsusceptibilityassayforrapiddiagnosisoflymphnodetuberculosisanddetectionofdrugresistance
AT gilmanroberth microscopicobservationdrugsusceptibilityassayforrapiddiagnosisoflymphnodetuberculosisanddetectionofdrugresistance
AT caviedesluz microscopicobservationdrugsusceptibilityassayforrapiddiagnosisoflymphnodetuberculosisanddetectionofdrugresistance
AT rizvihasan microscopicobservationdrugsusceptibilityassayforrapiddiagnosisoflymphnodetuberculosisanddetectionofdrugresistance
AT ticonaeduardo microscopicobservationdrugsusceptibilityassayforrapiddiagnosisoflymphnodetuberculosisanddetectionofdrugresistance
AT chavezgonzalo microscopicobservationdrugsusceptibilityassayforrapiddiagnosisoflymphnodetuberculosisanddetectionofdrugresistance
AT cabrerajoseluis microscopicobservationdrugsusceptibilityassayforrapiddiagnosisoflymphnodetuberculosisanddetectionofdrugresistance
AT matoseduardod microscopicobservationdrugsusceptibilityassayforrapiddiagnosisoflymphnodetuberculosisanddetectionofdrugresistance
AT evanscarltona microscopicobservationdrugsusceptibilityassayforrapiddiagnosisoflymphnodetuberculosisanddetectionofdrugresistance
AT mooredavidaj microscopicobservationdrugsusceptibilityassayforrapiddiagnosisoflymphnodetuberculosisanddetectionofdrugresistance
AT friedlandjons microscopicobservationdrugsusceptibilityassayforrapiddiagnosisoflymphnodetuberculosisanddetectionofdrugresistance

Ejemplares similares