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Cancer RNA-Seq Nexus: a database of phenotype-specific transcriptome profiling in cancer cells
The genome-wide transcriptome profiling of cancerous and normal tissue samples can provide insights into the molecular mechanisms of cancer initiation and progression. RNA Sequencing (RNA-Seq) is a revolutionary tool that has been used extensively in cancer research. However, no existing RNA-Seq dat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702907/ https://www.ncbi.nlm.nih.gov/pubmed/26602695 http://dx.doi.org/10.1093/nar/gkv1282 |
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author | Li, Jian-Rong Sun, Chuan-Hu Li, Wenyuan Chao, Rou-Fang Huang, Chieh-Chen Zhou, Xianghong Jasmine Liu, Chun-Chi |
author_facet | Li, Jian-Rong Sun, Chuan-Hu Li, Wenyuan Chao, Rou-Fang Huang, Chieh-Chen Zhou, Xianghong Jasmine Liu, Chun-Chi |
author_sort | Li, Jian-Rong |
collection | PubMed |
description | The genome-wide transcriptome profiling of cancerous and normal tissue samples can provide insights into the molecular mechanisms of cancer initiation and progression. RNA Sequencing (RNA-Seq) is a revolutionary tool that has been used extensively in cancer research. However, no existing RNA-Seq database provides all of the following features: (i) large-scale and comprehensive data archives and analyses, including coding-transcript profiling, long non-coding RNA (lncRNA) profiling and coexpression networks; (ii) phenotype-oriented data organization and searching and (iii) the visualization of expression profiles, differential expression and regulatory networks. We have constructed the first public database that meets these criteria, the Cancer RNA-Seq Nexus (CRN, http://syslab4.nchu.edu.tw/CRN). CRN has a user-friendly web interface designed to facilitate cancer research and personalized medicine. It is an open resource for intuitive data exploration, providing coding-transcript/lncRNA expression profiles to support researchers generating new hypotheses in cancer research and personalized medicine. |
format | Online Article Text |
id | pubmed-4702907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-47029072016-01-07 Cancer RNA-Seq Nexus: a database of phenotype-specific transcriptome profiling in cancer cells Li, Jian-Rong Sun, Chuan-Hu Li, Wenyuan Chao, Rou-Fang Huang, Chieh-Chen Zhou, Xianghong Jasmine Liu, Chun-Chi Nucleic Acids Res Database Issue The genome-wide transcriptome profiling of cancerous and normal tissue samples can provide insights into the molecular mechanisms of cancer initiation and progression. RNA Sequencing (RNA-Seq) is a revolutionary tool that has been used extensively in cancer research. However, no existing RNA-Seq database provides all of the following features: (i) large-scale and comprehensive data archives and analyses, including coding-transcript profiling, long non-coding RNA (lncRNA) profiling and coexpression networks; (ii) phenotype-oriented data organization and searching and (iii) the visualization of expression profiles, differential expression and regulatory networks. We have constructed the first public database that meets these criteria, the Cancer RNA-Seq Nexus (CRN, http://syslab4.nchu.edu.tw/CRN). CRN has a user-friendly web interface designed to facilitate cancer research and personalized medicine. It is an open resource for intuitive data exploration, providing coding-transcript/lncRNA expression profiles to support researchers generating new hypotheses in cancer research and personalized medicine. Oxford University Press 2016-01-04 2015-11-23 /pmc/articles/PMC4702907/ /pubmed/26602695 http://dx.doi.org/10.1093/nar/gkv1282 Text en © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Database Issue Li, Jian-Rong Sun, Chuan-Hu Li, Wenyuan Chao, Rou-Fang Huang, Chieh-Chen Zhou, Xianghong Jasmine Liu, Chun-Chi Cancer RNA-Seq Nexus: a database of phenotype-specific transcriptome profiling in cancer cells |
title | Cancer RNA-Seq Nexus: a database of phenotype-specific transcriptome profiling in cancer cells |
title_full | Cancer RNA-Seq Nexus: a database of phenotype-specific transcriptome profiling in cancer cells |
title_fullStr | Cancer RNA-Seq Nexus: a database of phenotype-specific transcriptome profiling in cancer cells |
title_full_unstemmed | Cancer RNA-Seq Nexus: a database of phenotype-specific transcriptome profiling in cancer cells |
title_short | Cancer RNA-Seq Nexus: a database of phenotype-specific transcriptome profiling in cancer cells |
title_sort | cancer rna-seq nexus: a database of phenotype-specific transcriptome profiling in cancer cells |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702907/ https://www.ncbi.nlm.nih.gov/pubmed/26602695 http://dx.doi.org/10.1093/nar/gkv1282 |
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