A systematic investigation of production of synthetic prions from recombinant prion protein

According to the protein-only hypothesis, infectious mammalian prions, which exist as distinct strains with discrete biological properties, consist of multichain assemblies of misfolded cellular prion protein (PrP). A critical test would be to produce prion strains synthetically from defined compone...

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Detalles Bibliográficos
Autores principales: Schmidt, Christian, Fizet, Jeremie, Properzi, Francesca, Batchelor, Mark, Sandberg, Malin K., Edgeworth, Julie A., Afran, Louise, Ho, Sammy, Badhan, Anjna, Klier, Steffi, Linehan, Jacqueline M., Brandner, Sebastian, Hosszu, Laszlo L. P., Tattum, M. Howard, Jat, Parmjit, Clarke, Anthony R., Klöhn, Peter C., Wadsworth, Jonathan D. F., Jackson, Graham S., Collinge, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703057/
https://www.ncbi.nlm.nih.gov/pubmed/26631378
http://dx.doi.org/10.1098/rsob.150165

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