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Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled

Dishevelled is a pivot in Wnt signal transduction, controlling both β-catenin-dependent transcription to specify proliferative cell fates, and cell polarity and other non-nuclear events in post-mitotic cells. In response to Wnt signals, or when present at high levels, Dishevelled forms signalosomes...

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Detalles Bibliográficos
Autores principales:	Mund, Thomas, Graeb, Michael, Mieszczanek, Juliusz, Gammons, Melissa, Pelham, Hugh R. B., Bienz, Mariann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703060/ https://www.ncbi.nlm.nih.gov/pubmed/26701932 http://dx.doi.org/10.1098/rsob.150185

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