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A molecular mechanism underlying gustatory memory trace for an association in the insular cortex

Events separated in time are associatively learned in trace conditioning, recruiting more neuronal circuits and molecular mechanisms than in delay conditioning. However, it remains unknown whether a given sensory memory trace is being maintained as a unitary item to associate. Here, we used conditio...

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Detalles Bibliográficos
Autores principales: Adaikkan, Chinnakkaruppan, Rosenblum, Kobi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703067/
https://www.ncbi.nlm.nih.gov/pubmed/26452094
http://dx.doi.org/10.7554/eLife.07582
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author Adaikkan, Chinnakkaruppan
Rosenblum, Kobi
author_facet Adaikkan, Chinnakkaruppan
Rosenblum, Kobi
author_sort Adaikkan, Chinnakkaruppan
collection PubMed
description Events separated in time are associatively learned in trace conditioning, recruiting more neuronal circuits and molecular mechanisms than in delay conditioning. However, it remains unknown whether a given sensory memory trace is being maintained as a unitary item to associate. Here, we used conditioned taste aversion learning in the rat model, wherein animals associate a novel taste with visceral nausea, and demonstrate that there are two parallel memory traces of a novel taste: a short-duration robust trace, lasting approximately 3 hr, and a parallel long-duration weak one, lasting up to 8 hr, and dependent on the strong trace for its formation. Moreover, only the early robust trace is maintained by a NMDAR-dependent CaMKII- AMPAR pathway in the insular cortex. These findings suggest that a memory trace undergoes rapid modifications, and that the mechanisms underlying trace associative learning differ when items in the memory are experienced at different time points. DOI: http://dx.doi.org/10.7554/eLife.07582.001
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spelling pubmed-47030672016-03-17 A molecular mechanism underlying gustatory memory trace for an association in the insular cortex Adaikkan, Chinnakkaruppan Rosenblum, Kobi eLife Neuroscience Events separated in time are associatively learned in trace conditioning, recruiting more neuronal circuits and molecular mechanisms than in delay conditioning. However, it remains unknown whether a given sensory memory trace is being maintained as a unitary item to associate. Here, we used conditioned taste aversion learning in the rat model, wherein animals associate a novel taste with visceral nausea, and demonstrate that there are two parallel memory traces of a novel taste: a short-duration robust trace, lasting approximately 3 hr, and a parallel long-duration weak one, lasting up to 8 hr, and dependent on the strong trace for its formation. Moreover, only the early robust trace is maintained by a NMDAR-dependent CaMKII- AMPAR pathway in the insular cortex. These findings suggest that a memory trace undergoes rapid modifications, and that the mechanisms underlying trace associative learning differ when items in the memory are experienced at different time points. DOI: http://dx.doi.org/10.7554/eLife.07582.001 eLife Sciences Publications, Ltd 2015-10-09 /pmc/articles/PMC4703067/ /pubmed/26452094 http://dx.doi.org/10.7554/eLife.07582 Text en © 2015, Adaikkan et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Adaikkan, Chinnakkaruppan
Rosenblum, Kobi
A molecular mechanism underlying gustatory memory trace for an association in the insular cortex
title A molecular mechanism underlying gustatory memory trace for an association in the insular cortex
title_full A molecular mechanism underlying gustatory memory trace for an association in the insular cortex
title_fullStr A molecular mechanism underlying gustatory memory trace for an association in the insular cortex
title_full_unstemmed A molecular mechanism underlying gustatory memory trace for an association in the insular cortex
title_short A molecular mechanism underlying gustatory memory trace for an association in the insular cortex
title_sort molecular mechanism underlying gustatory memory trace for an association in the insular cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703067/
https://www.ncbi.nlm.nih.gov/pubmed/26452094
http://dx.doi.org/10.7554/eLife.07582
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