ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43

TAR-DNA-binding protein-43 (TDP-43) C-terminus encodes a prion-like domain widely presented in RNA-binding proteins, which functions to form dynamic oligomers and also, amazingly, hosts most amyotrophic lateral sclerosis (ALS)-causing mutations. Here, as facilitated by our previous discovery, by cir...

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Detalles Bibliográficos
Autores principales: Lim, Liangzhong, Wei, Yuanyuan, Lu, Yimei, Song, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703307/
https://www.ncbi.nlm.nih.gov/pubmed/26735904
http://dx.doi.org/10.1371/journal.pbio.1002338

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