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Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development
Abnormal activation of SETBP1 through overexpression or missense mutations is highly recurrent in various myeloid malignancies; however, it is unclear whether such activation alone is able to induce leukemia development. Here we show that Setbp1 overexpression in mouse bone marrow progenitors throug...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703539/ https://www.ncbi.nlm.nih.gov/pubmed/26205084 http://dx.doi.org/10.1038/leu.2015.200 |