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Disruption of Cytochrome c Oxidase Function Induces Warburg Effect and Metabolic Reprogramming

Defects in mitochondrial oxidative phosphorylation complexes, altered bioenergetics and metabolic shift are often seen in cancers. Here we show a role for the dysfunction of electron transport chain component, cytochrome c oxidase (CcO) in cancer progression. We show that genetic silencing of the Cc...

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Detalles Bibliográficos
Autores principales:	Srinivasan, Satish, Guha, Manti, Dong, Dawei W, Whelan, Kelly A, Ruthel, Gordon, Uchikado, Yasuto, Natsugoe, Shoji, Nakagawa, Hiroshi, Avadhani, Narayan G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703574/ https://www.ncbi.nlm.nih.gov/pubmed/26148236 http://dx.doi.org/10.1038/onc.2015.227

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