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A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study
Elevated homocysteine concentrations are associated with a decline in physical function in elderly persons. Homocysteine-lowering therapy may slow down this decline. This study aimed to examine the effect of a 2-year intervention of vitamin B12 and folic acid supplementation on physical performance,...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703626/ https://www.ncbi.nlm.nih.gov/pubmed/26412463 http://dx.doi.org/10.1007/s00223-015-0059-5 |
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author | Swart, Karin M. A. Ham, Annelies C. van Wijngaarden, Janneke P. Enneman, Anke W. van Dijk, Suzanne C. Sohl, Evelien Brouwer-Brolsma, Elske M. van der Zwaluw, Nikita L. Carola Zillikens, M. Dhonukshe-Rutten, Rosalie A. M. van der Velde, Nathalie Brug, Johannes Uitterlinden, André G. de Groot, Lisette C. P. G. M. Lips, Paul van Schoor, Natasja M. |
author_facet | Swart, Karin M. A. Ham, Annelies C. van Wijngaarden, Janneke P. Enneman, Anke W. van Dijk, Suzanne C. Sohl, Evelien Brouwer-Brolsma, Elske M. van der Zwaluw, Nikita L. Carola Zillikens, M. Dhonukshe-Rutten, Rosalie A. M. van der Velde, Nathalie Brug, Johannes Uitterlinden, André G. de Groot, Lisette C. P. G. M. Lips, Paul van Schoor, Natasja M. |
author_sort | Swart, Karin M. A. |
collection | PubMed |
description | Elevated homocysteine concentrations are associated with a decline in physical function in elderly persons. Homocysteine-lowering therapy may slow down this decline. This study aimed to examine the effect of a 2-year intervention of vitamin B12 and folic acid supplementation on physical performance, handgrip strength, and risk of falling in elderly subjects in a double-blind, randomized placebo-controlled trial. Participants aged ≥65 years with elevated plasma homocysteine concentrations [12–50 µmol/L (n = 2919)] were randomly assigned to daily supplementation of 500 µg vitamin B12, 400 µg folic acid, and 600 IU vitamin D3, or to placebo with 600 IU vitamin D3. Physical performance (range 0–12) and handgrip strength (kg) were measured at baseline and after 2 years. Falls were reported prospectively on a research calendar. Intention-to-treat (primary) and per-protocol (secondary) analyses were performed. Physical performance level and handgrip strength significantly decreased during the follow-up period, but this decline did not differ between groups. Moreover, time to first fall was not significantly different (HR: 1.0, 95 % CI 0.9–1.2). Secondary analyses on a per-protocol base identified an interaction effect with age on physical performance. In addition, the treatment was associated with higher follow-up scores on the walking test (cumulative OR: 1.3, 95 % CI 1.1–1.5). Two-year supplementation of vitamin B12 and folic acid was neither effective in reducing the age-related decline in physical performance and handgrip strength, nor in the prevention of falling in elderly persons. Despite the overall null-effect, the results provide indications for a positive effect of the intervention on gait, as well as on physical performance among compliant persons >80 years. These effects should be further tested in future studies. |
format | Online Article Text |
id | pubmed-4703626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-47036262016-01-12 A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study Swart, Karin M. A. Ham, Annelies C. van Wijngaarden, Janneke P. Enneman, Anke W. van Dijk, Suzanne C. Sohl, Evelien Brouwer-Brolsma, Elske M. van der Zwaluw, Nikita L. Carola Zillikens, M. Dhonukshe-Rutten, Rosalie A. M. van der Velde, Nathalie Brug, Johannes Uitterlinden, André G. de Groot, Lisette C. P. G. M. Lips, Paul van Schoor, Natasja M. Calcif Tissue Int Original Research Elevated homocysteine concentrations are associated with a decline in physical function in elderly persons. Homocysteine-lowering therapy may slow down this decline. This study aimed to examine the effect of a 2-year intervention of vitamin B12 and folic acid supplementation on physical performance, handgrip strength, and risk of falling in elderly subjects in a double-blind, randomized placebo-controlled trial. Participants aged ≥65 years with elevated plasma homocysteine concentrations [12–50 µmol/L (n = 2919)] were randomly assigned to daily supplementation of 500 µg vitamin B12, 400 µg folic acid, and 600 IU vitamin D3, or to placebo with 600 IU vitamin D3. Physical performance (range 0–12) and handgrip strength (kg) were measured at baseline and after 2 years. Falls were reported prospectively on a research calendar. Intention-to-treat (primary) and per-protocol (secondary) analyses were performed. Physical performance level and handgrip strength significantly decreased during the follow-up period, but this decline did not differ between groups. Moreover, time to first fall was not significantly different (HR: 1.0, 95 % CI 0.9–1.2). Secondary analyses on a per-protocol base identified an interaction effect with age on physical performance. In addition, the treatment was associated with higher follow-up scores on the walking test (cumulative OR: 1.3, 95 % CI 1.1–1.5). Two-year supplementation of vitamin B12 and folic acid was neither effective in reducing the age-related decline in physical performance and handgrip strength, nor in the prevention of falling in elderly persons. Despite the overall null-effect, the results provide indications for a positive effect of the intervention on gait, as well as on physical performance among compliant persons >80 years. These effects should be further tested in future studies. Springer US 2015-09-28 2016 /pmc/articles/PMC4703626/ /pubmed/26412463 http://dx.doi.org/10.1007/s00223-015-0059-5 Text en © © The Author(s) 2015. This article is published with open access at Springerlink.com 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Research Swart, Karin M. A. Ham, Annelies C. van Wijngaarden, Janneke P. Enneman, Anke W. van Dijk, Suzanne C. Sohl, Evelien Brouwer-Brolsma, Elske M. van der Zwaluw, Nikita L. Carola Zillikens, M. Dhonukshe-Rutten, Rosalie A. M. van der Velde, Nathalie Brug, Johannes Uitterlinden, André G. de Groot, Lisette C. P. G. M. Lips, Paul van Schoor, Natasja M. A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study |
title | A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study |
title_full | A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study |
title_fullStr | A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study |
title_full_unstemmed | A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study |
title_short | A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study |
title_sort | randomized controlled trial to examine the effect of 2-year vitamin b12 and folic acid supplementation on physical performance, strength, and falling: additional findings from the b-proof study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703626/ https://www.ncbi.nlm.nih.gov/pubmed/26412463 http://dx.doi.org/10.1007/s00223-015-0059-5 |
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