Flecainide in Amyotrophic Lateral Sclerosis as a Neuroprotective Strategy (FANS): A Randomized Placebo-Controlled Trial

BACKGROUND: Abnormalities in membrane excitability and Na(+) channel function are characteristic of amyotrophic lateral sclerosis (ALS). We aimed to examine the neuroprotective potential, safety and tolerability of the Na(+) channel blocker and membrane stabiliser flecainide in ALS. METHODS: A doubl...

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Detalles Bibliográficos
Autores principales: Park, Susanna B., Vucic, Steve, Cheah, Benjamin C., Lin, Cindy S.-Y., Kirby, Adrienne, Mann, Kristy P., Zoing, Margie C., Winhammar, Jennica, Kiernan, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703720/
https://www.ncbi.nlm.nih.gov/pubmed/26844270
http://dx.doi.org/10.1016/j.ebiom.2015.11.022

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