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Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients

Hepatitis E virus (HEV) infection may cause acute hepatitis and lead to hepatic failure in developing and developed countries. We studied HEV seroprevalences in patients with hepatitis B virus (HBV) infection to understand the consequences of HEV superinfection in a Vietnamese population. This cross...

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Autores principales: Hoan, Nghiem Xuan, Tong, Hoang Van, Hecht, Nicole, Sy, Bui Tien, Marcinek, Patrick, Meyer, Christian G., Song, Le Huu, Toan, Nguyen Linh, Kurreck, Jens, Kremsner, Peter G., Bock, C-Thomas, Velavan, Thirumalaisamy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703726/
https://www.ncbi.nlm.nih.gov/pubmed/26844288
http://dx.doi.org/10.1016/j.ebiom.2015.11.020
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author Hoan, Nghiem Xuan
Tong, Hoang Van
Hecht, Nicole
Sy, Bui Tien
Marcinek, Patrick
Meyer, Christian G.
Song, Le Huu
Toan, Nguyen Linh
Kurreck, Jens
Kremsner, Peter G.
Bock, C-Thomas
Velavan, Thirumalaisamy P.
author_facet Hoan, Nghiem Xuan
Tong, Hoang Van
Hecht, Nicole
Sy, Bui Tien
Marcinek, Patrick
Meyer, Christian G.
Song, Le Huu
Toan, Nguyen Linh
Kurreck, Jens
Kremsner, Peter G.
Bock, C-Thomas
Velavan, Thirumalaisamy P.
author_sort Hoan, Nghiem Xuan
collection PubMed
description Hepatitis E virus (HEV) infection may cause acute hepatitis and lead to hepatic failure in developing and developed countries. We studied HEV seroprevalences in patients with hepatitis B virus (HBV) infection to understand the consequences of HEV superinfection in a Vietnamese population. This cross-sectional study was conducted from 2012 to 2013 and included 1318 Vietnamese patients with HBV-related liver diseases and 340 healthy controls. The case group included patients with acute (n = 26) and chronic hepatitis B (n = 744), liver cirrhosis (n = 160), hepatocellular carcinoma (n = 166) and patients with both liver cirrhosis and hepatocellular carcinoma (n = 222). Anti-HEV IgG and IgM antibodies were assessed in patients and controls by ELISA. HEV-RNA was identified by PCR assays and sequencing. Seroprevalences of anti-HEV IgG among hepatitis B patients and controls were 45% and 31%, respectively (adjusted P = 0.034). Anti-HEV IgM seroprevalences were 11.6% and 4.7% in patients and controls, respectively (adjusted P = 0.005). Seroprevalences were higher among the elder individuals. When stratifying for patient groups, those with liver cirrhosis had the highest anti-HEV IgG (52%) and anti-HEV IgM (19%) seroprevalences. Hepatitis B patients with current HEV infection had abnormal liver function tests compared to patients with past or without HEV infection. One HEV isolate was retrieved from a patient with both liver cirrhosis and hepatocellular carcinoma and identified as HEV genotype 3. This study indicates high prevalences of HEV infection in Vietnamese HBV patients and among healthy individuals and shows that HEV superinfection may influence the outcome and progression of HBV-related liver disease.
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spelling pubmed-47037262016-02-03 Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients Hoan, Nghiem Xuan Tong, Hoang Van Hecht, Nicole Sy, Bui Tien Marcinek, Patrick Meyer, Christian G. Song, Le Huu Toan, Nguyen Linh Kurreck, Jens Kremsner, Peter G. Bock, C-Thomas Velavan, Thirumalaisamy P. EBioMedicine Research Article Hepatitis E virus (HEV) infection may cause acute hepatitis and lead to hepatic failure in developing and developed countries. We studied HEV seroprevalences in patients with hepatitis B virus (HBV) infection to understand the consequences of HEV superinfection in a Vietnamese population. This cross-sectional study was conducted from 2012 to 2013 and included 1318 Vietnamese patients with HBV-related liver diseases and 340 healthy controls. The case group included patients with acute (n = 26) and chronic hepatitis B (n = 744), liver cirrhosis (n = 160), hepatocellular carcinoma (n = 166) and patients with both liver cirrhosis and hepatocellular carcinoma (n = 222). Anti-HEV IgG and IgM antibodies were assessed in patients and controls by ELISA. HEV-RNA was identified by PCR assays and sequencing. Seroprevalences of anti-HEV IgG among hepatitis B patients and controls were 45% and 31%, respectively (adjusted P = 0.034). Anti-HEV IgM seroprevalences were 11.6% and 4.7% in patients and controls, respectively (adjusted P = 0.005). Seroprevalences were higher among the elder individuals. When stratifying for patient groups, those with liver cirrhosis had the highest anti-HEV IgG (52%) and anti-HEV IgM (19%) seroprevalences. Hepatitis B patients with current HEV infection had abnormal liver function tests compared to patients with past or without HEV infection. One HEV isolate was retrieved from a patient with both liver cirrhosis and hepatocellular carcinoma and identified as HEV genotype 3. This study indicates high prevalences of HEV infection in Vietnamese HBV patients and among healthy individuals and shows that HEV superinfection may influence the outcome and progression of HBV-related liver disease. Elsevier 2015-11-11 /pmc/articles/PMC4703726/ /pubmed/26844288 http://dx.doi.org/10.1016/j.ebiom.2015.11.020 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Hoan, Nghiem Xuan
Tong, Hoang Van
Hecht, Nicole
Sy, Bui Tien
Marcinek, Patrick
Meyer, Christian G.
Song, Le Huu
Toan, Nguyen Linh
Kurreck, Jens
Kremsner, Peter G.
Bock, C-Thomas
Velavan, Thirumalaisamy P.
Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients
title Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients
title_full Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients
title_fullStr Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients
title_full_unstemmed Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients
title_short Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients
title_sort hepatitis e virus superinfection and clinical progression in hepatitis b patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703726/
https://www.ncbi.nlm.nih.gov/pubmed/26844288
http://dx.doi.org/10.1016/j.ebiom.2015.11.020
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