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PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer

The p38 MAP kinase is a promising cancer drug target but its therapeutic effect is not fully understood. Here we report that the response of colorectal cancer (CRC) to p38 inhibitors (p38i) is highly variable: while p38i induces regression of one subgroup of CRCs, it stimulates growth of another sub...

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Detalles Bibliográficos
Autores principales:	Zhang, Yanjie, Wang, Xiaowen, Qin, Xiaoyu, Wang, Xinxin, Liu, Feng, White, Eileen, Zheng, X.F. Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703732/ https://www.ncbi.nlm.nih.gov/pubmed/26844273 http://dx.doi.org/10.1016/j.ebiom.2015.11.031

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