Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis

The transcription factor, runt-related transcription factor 2 (Runx2), plays a pivotal role in the differentiation of the mesenchymal stem cells to the osteochondroblast lineages. We found by the drug repositioning strategy that a proton pump inhibitor, lansoprazole, enhances nuclear accumulation of...

Descripción completa

Detalles Bibliográficos
Autores principales: Mishima, Kenichi, Kitoh, Hiroshi, Ohkawara, Bisei, Okuno, Tatsuya, Ito, Mikako, Masuda, Akio, Ishiguro, Naoki, Ohno, Kinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703748/
https://www.ncbi.nlm.nih.gov/pubmed/26844285
http://dx.doi.org/10.1016/j.ebiom.2015.11.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703748/
https://www.ncbi.nlm.nih.gov/pubmed/26844285
http://dx.doi.org/10.1016/j.ebiom.2015.11.024

Ejemplares similares