Cargando…

New Concepts in Malaria Pathogenesis: The Role of the Renin-Angiotensin System

Malaria is a worldwide health problem leading the death of millions of people. The disease is induced by different species of protozoa parasites from the genus Plasmodium. In humans, Plasmodium falciparum is the most dangerous species responsible for severe disease. Despite all efforts to establish...

Descripción completa

Detalles Bibliográficos
Autores principales: Silva, Leandro S., Silva-Filho, João Luiz, Caruso-Neves, Celso, Pinheiro, Ana Acacia S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703750/
https://www.ncbi.nlm.nih.gov/pubmed/26779452
http://dx.doi.org/10.3389/fcimb.2015.00103
_version_ 1782408769456570368
author Silva, Leandro S.
Silva-Filho, João Luiz
Caruso-Neves, Celso
Pinheiro, Ana Acacia S.
author_facet Silva, Leandro S.
Silva-Filho, João Luiz
Caruso-Neves, Celso
Pinheiro, Ana Acacia S.
author_sort Silva, Leandro S.
collection PubMed
description Malaria is a worldwide health problem leading the death of millions of people. The disease is induced by different species of protozoa parasites from the genus Plasmodium. In humans, Plasmodium falciparum is the most dangerous species responsible for severe disease. Despite all efforts to establish the pathogenesis of malaria, it is far from being fully understood. In addition, resistance to existing drugs has developed in several strains and the development of new effective compounds to fight these parasites is a major issue. Recent discoveries indicate the potential role of the renin-angiotensin system (RAS) in malaria infection. Angiotensin receptors have not been described in the parasite genome, however several reports in the literature suggest a direct effect of angiotensin-derived peptides on different aspects of the host-parasite interaction. The aim of this review is to highlight new findings on the involvement of the RAS in parasite development and in the regulation of the host immune response in an attempt to expand our knowledge of the pathogenesis of this disease.
format Online
Article
Text
id pubmed-4703750
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-47037502016-01-15 New Concepts in Malaria Pathogenesis: The Role of the Renin-Angiotensin System Silva, Leandro S. Silva-Filho, João Luiz Caruso-Neves, Celso Pinheiro, Ana Acacia S. Front Cell Infect Microbiol Microbiology Malaria is a worldwide health problem leading the death of millions of people. The disease is induced by different species of protozoa parasites from the genus Plasmodium. In humans, Plasmodium falciparum is the most dangerous species responsible for severe disease. Despite all efforts to establish the pathogenesis of malaria, it is far from being fully understood. In addition, resistance to existing drugs has developed in several strains and the development of new effective compounds to fight these parasites is a major issue. Recent discoveries indicate the potential role of the renin-angiotensin system (RAS) in malaria infection. Angiotensin receptors have not been described in the parasite genome, however several reports in the literature suggest a direct effect of angiotensin-derived peptides on different aspects of the host-parasite interaction. The aim of this review is to highlight new findings on the involvement of the RAS in parasite development and in the regulation of the host immune response in an attempt to expand our knowledge of the pathogenesis of this disease. Frontiers Media S.A. 2016-01-07 /pmc/articles/PMC4703750/ /pubmed/26779452 http://dx.doi.org/10.3389/fcimb.2015.00103 Text en Copyright © 2016 Silva, Silva-Filho, Caruso-Neves and Pinheiro. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Silva, Leandro S.
Silva-Filho, João Luiz
Caruso-Neves, Celso
Pinheiro, Ana Acacia S.
New Concepts in Malaria Pathogenesis: The Role of the Renin-Angiotensin System
title New Concepts in Malaria Pathogenesis: The Role of the Renin-Angiotensin System
title_full New Concepts in Malaria Pathogenesis: The Role of the Renin-Angiotensin System
title_fullStr New Concepts in Malaria Pathogenesis: The Role of the Renin-Angiotensin System
title_full_unstemmed New Concepts in Malaria Pathogenesis: The Role of the Renin-Angiotensin System
title_short New Concepts in Malaria Pathogenesis: The Role of the Renin-Angiotensin System
title_sort new concepts in malaria pathogenesis: the role of the renin-angiotensin system
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703750/
https://www.ncbi.nlm.nih.gov/pubmed/26779452
http://dx.doi.org/10.3389/fcimb.2015.00103
work_keys_str_mv AT silvaleandros newconceptsinmalariapathogenesistheroleofthereninangiotensinsystem
AT silvafilhojoaoluiz newconceptsinmalariapathogenesistheroleofthereninangiotensinsystem
AT carusonevescelso newconceptsinmalariapathogenesistheroleofthereninangiotensinsystem
AT pinheiroanaacacias newconceptsinmalariapathogenesistheroleofthereninangiotensinsystem