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Phenotypic Screening Approaches to Develop Aurora Kinase Inhibitors: Drug Discovery Perspectives
Targeting mitotic regulators as a strategy to fight cancer implies the development of drugs against key proteins, such as Aurora-A and -B. Current drugs, which target mitosis through a general mechanism of action (stabilization/destabilization of microtubules), have several side effects (neutropenia...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703775/ https://www.ncbi.nlm.nih.gov/pubmed/26779442 http://dx.doi.org/10.3389/fonc.2015.00299 |