Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine

Genome-scale metabolic models (GEMs) have become a popular tool for systems biology, and they have been used in many fields such as industrial biotechnology and systems medicine. Since more and more studies are being conducted using GEMs, they have recently received considerable attention. In this r...

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Detalles Bibliográficos
Autores principales: Zhang, Cheng, Hua, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703781/
https://www.ncbi.nlm.nih.gov/pubmed/26779040
http://dx.doi.org/10.3389/fphys.2015.00413
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author Zhang, Cheng
Hua, Qiang
author_facet Zhang, Cheng
Hua, Qiang
author_sort Zhang, Cheng
collection PubMed
description Genome-scale metabolic models (GEMs) have become a popular tool for systems biology, and they have been used in many fields such as industrial biotechnology and systems medicine. Since more and more studies are being conducted using GEMs, they have recently received considerable attention. In this review, we introduce the basic concept of GEMs and provide an overview of their applications in biotechnology, systems medicine, and some other fields. In addition, we describe the general principle of the applications and analyses built on GEMs. The purpose of this review is to introduce the application of GEMs in biological analysis and to promote its wider use by biologists.
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spelling pubmed-47037812016-01-15 Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine Zhang, Cheng Hua, Qiang Front Physiol Physiology Genome-scale metabolic models (GEMs) have become a popular tool for systems biology, and they have been used in many fields such as industrial biotechnology and systems medicine. Since more and more studies are being conducted using GEMs, they have recently received considerable attention. In this review, we introduce the basic concept of GEMs and provide an overview of their applications in biotechnology, systems medicine, and some other fields. In addition, we describe the general principle of the applications and analyses built on GEMs. The purpose of this review is to introduce the application of GEMs in biological analysis and to promote its wider use by biologists. Frontiers Media S.A. 2016-01-07 /pmc/articles/PMC4703781/ /pubmed/26779040 http://dx.doi.org/10.3389/fphys.2015.00413 Text en Copyright © 2016 Zhang and Hua. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Zhang, Cheng
Hua, Qiang
Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine
title Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine
title_full Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine
title_fullStr Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine
title_full_unstemmed Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine
title_short Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine
title_sort applications of genome-scale metabolic models in biotechnology and systems medicine
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703781/
https://www.ncbi.nlm.nih.gov/pubmed/26779040
http://dx.doi.org/10.3389/fphys.2015.00413
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AT huaqiang applicationsofgenomescalemetabolicmodelsinbiotechnologyandsystemsmedicine

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