Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA

Coxiella burnetii is a highly infectious bacterium that promotes its own replication in macrophages by inhibiting several host cell responses. Here, we show that C. burnetii inhibits caspase-1 activation in primary mouse macrophages. By using co-infection experiments, we determine that the infection...

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Detalles Bibliográficos
Autores principales: Cunha, Larissa D., Ribeiro, Juliana M., Fernandes, Talita D., Massis, Liliana M., Khoo, Chen Ai, Moffatt, Jennifer H., Newton, Hayley J., Roy, Craig R., Zamboni, Dario S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703858/
https://www.ncbi.nlm.nih.gov/pubmed/26687278
http://dx.doi.org/10.1038/ncomms10205

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