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Transcriptional elongation requires DNA break-induced signalling

We have previously shown that RNA polymerase II (Pol II) pause release and transcriptional elongation involve phosphorylation of the factor TRIM28 by the DNA damage response (DDR) kinases ATM and DNA-PK. Here we report a significant role for DNA breaks and DDR signalling in the mechanisms of transcr...

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Detalles Bibliográficos
Autores principales:	Bunch, Heeyoun, Lawney, Brian P., Lin, Yu-Fen, Asaithamby, Aroumougame, Murshid, Ayesha, Wang, Yaoyu E., Chen, Benjamin P. C., Calderwood, Stuart K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703865/ https://www.ncbi.nlm.nih.gov/pubmed/26671524 http://dx.doi.org/10.1038/ncomms10191

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