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Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression

In primates, puberty is unleashed by increased GnRH release from the hypothalamus following an interval of juvenile quiescence. GWAS implicates Zinc finger (ZNF) genes in timing human puberty. Here we show that hypothalamic expression of several ZNFs decreased in agonadal male monkeys in association...

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Detalles Bibliográficos
Autores principales:	Lomniczi, Alejandro, Wright, Hollis, Castellano, Juan Manuel, Matagne, Valerie, Toro, Carlos A., Ramaswamy, Suresh, Plant, Tony M., Ojeda, Sergio R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703871/ https://www.ncbi.nlm.nih.gov/pubmed/26671628 http://dx.doi.org/10.1038/ncomms10195

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