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Autopsy Analysis may Contribute to Establish Actual Incidence of Second Primary Malignancies in Myeloma

Second primary malignancies (SPMs) are issues for patients with multiple myeloma (MM). There may have been some limitations in prior studies, such as difficulties in a longer follow-up and absence of established screening methods. Therefore, we studied autopsied cases to overcome these limitations....

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Autores principales: Takano, Junichiro, Hagiwara, Shotaro, Miwa, Akiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703915/
https://www.ncbi.nlm.nih.gov/pubmed/26788269
http://dx.doi.org/10.4081/rt.2015.5949
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author Takano, Junichiro
Hagiwara, Shotaro
Miwa, Akiyoshi
author_facet Takano, Junichiro
Hagiwara, Shotaro
Miwa, Akiyoshi
author_sort Takano, Junichiro
collection PubMed
description Second primary malignancies (SPMs) are issues for patients with multiple myeloma (MM). There may have been some limitations in prior studies, such as difficulties in a longer follow-up and absence of established screening methods. Therefore, we studied autopsied cases to overcome these limitations. This study aimed to examine SPMs using autopsy reports. Ninety-one cases of MM autopsied at our institution from 1979 to 2013 were analyzed. Median age of autopsied patients was 64.1 years, and proportion of male/female was 59/32. Autopsy was performed in 35.3% of patients died of MM. There were five cases of SPMs with a median confirmation time of 38 (12-132) months from the diagnosis of MM. In three of the five patients, the diagnosis of SPMs was established at autopsy. One case was of myelodysplastic syndrome, and the others were of non-hematological malignancies. The annual risk of SPM estimated using the Kaplan-Meier method was approximately 1%. Three of five SPM cases were detected at autopsy. Analysis of autopsy may contribute to estimate the actual risk of SPMs in MM.
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spelling pubmed-47039152016-01-19 Autopsy Analysis may Contribute to Establish Actual Incidence of Second Primary Malignancies in Myeloma Takano, Junichiro Hagiwara, Shotaro Miwa, Akiyoshi Rare Tumors Article Second primary malignancies (SPMs) are issues for patients with multiple myeloma (MM). There may have been some limitations in prior studies, such as difficulties in a longer follow-up and absence of established screening methods. Therefore, we studied autopsied cases to overcome these limitations. This study aimed to examine SPMs using autopsy reports. Ninety-one cases of MM autopsied at our institution from 1979 to 2013 were analyzed. Median age of autopsied patients was 64.1 years, and proportion of male/female was 59/32. Autopsy was performed in 35.3% of patients died of MM. There were five cases of SPMs with a median confirmation time of 38 (12-132) months from the diagnosis of MM. In three of the five patients, the diagnosis of SPMs was established at autopsy. One case was of myelodysplastic syndrome, and the others were of non-hematological malignancies. The annual risk of SPM estimated using the Kaplan-Meier method was approximately 1%. Three of five SPM cases were detected at autopsy. Analysis of autopsy may contribute to estimate the actual risk of SPMs in MM. PAGEPress Publications, Pavia, Italy 2015-12-29 /pmc/articles/PMC4703915/ /pubmed/26788269 http://dx.doi.org/10.4081/rt.2015.5949 Text en ©Copyright J. Takano et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Takano, Junichiro
Hagiwara, Shotaro
Miwa, Akiyoshi
Autopsy Analysis may Contribute to Establish Actual Incidence of Second Primary Malignancies in Myeloma
title Autopsy Analysis may Contribute to Establish Actual Incidence of Second Primary Malignancies in Myeloma
title_full Autopsy Analysis may Contribute to Establish Actual Incidence of Second Primary Malignancies in Myeloma
title_fullStr Autopsy Analysis may Contribute to Establish Actual Incidence of Second Primary Malignancies in Myeloma
title_full_unstemmed Autopsy Analysis may Contribute to Establish Actual Incidence of Second Primary Malignancies in Myeloma
title_short Autopsy Analysis may Contribute to Establish Actual Incidence of Second Primary Malignancies in Myeloma
title_sort autopsy analysis may contribute to establish actual incidence of second primary malignancies in myeloma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703915/
https://www.ncbi.nlm.nih.gov/pubmed/26788269
http://dx.doi.org/10.4081/rt.2015.5949
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