T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma

Primary central nervous system (PCNSL) lymphoma is an aggressive extranodal non-Hodgkin lymphoma, and most cases are classified as diffuse large B-cell lymphoma (DLBCL) by histology. T-cell/histiocyte-rich large B-cell lymphoma (TCRLBCL) represents a distinct subtype of diffuse large B-cell lymphoma...

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Autores principales: Advani, Pooja, Starr, Jason, Swaika, Abhisek, Jiang, Liuyan, Qiu, Yushi, Li, Zhimin, Tun, Han W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703926/
https://www.ncbi.nlm.nih.gov/pubmed/26788280
http://dx.doi.org/10.4081/rt.2015.6084
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author Advani, Pooja
Starr, Jason
Swaika, Abhisek
Jiang, Liuyan
Qiu, Yushi
Li, Zhimin
Tun, Han W.
author_facet Advani, Pooja
Starr, Jason
Swaika, Abhisek
Jiang, Liuyan
Qiu, Yushi
Li, Zhimin
Tun, Han W.
author_sort Advani, Pooja
collection PubMed
description Primary central nervous system (PCNSL) lymphoma is an aggressive extranodal non-Hodgkin lymphoma, and most cases are classified as diffuse large B-cell lymphoma (DLBCL) by histology. T-cell/histiocyte-rich large B-cell lymphoma (TCRLBCL) represents a distinct subtype of diffuse large B-cell lymphoma and is characterized by the presence of scattered large neoplastic B-cells in a background of abundant T-cells and histiocytes. This is in contrast to the dense perivascular cuffing of neoplastic B-cells in classic DLBCL. T-cell/histiocyte-rich large B-cell lymphoma should be considered in PCNSL cases in which neoplastic B-cells are sparse and scattered. Immunohistochemistry will help identify the B-cells and surrounding infiltrate rich in Tlymphocytes and histiocytes. Future studies exploring the biology of TCRLBCL and the crosstalk between the neoplastic cells and the surrounding inflammatory infiltrate may provide exciting prospects for future therapies for TCRLBCL.
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spelling pubmed-47039262016-01-19 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma Advani, Pooja Starr, Jason Swaika, Abhisek Jiang, Liuyan Qiu, Yushi Li, Zhimin Tun, Han W. Rare Tumors Case Report Primary central nervous system (PCNSL) lymphoma is an aggressive extranodal non-Hodgkin lymphoma, and most cases are classified as diffuse large B-cell lymphoma (DLBCL) by histology. T-cell/histiocyte-rich large B-cell lymphoma (TCRLBCL) represents a distinct subtype of diffuse large B-cell lymphoma and is characterized by the presence of scattered large neoplastic B-cells in a background of abundant T-cells and histiocytes. This is in contrast to the dense perivascular cuffing of neoplastic B-cells in classic DLBCL. T-cell/histiocyte-rich large B-cell lymphoma should be considered in PCNSL cases in which neoplastic B-cells are sparse and scattered. Immunohistochemistry will help identify the B-cells and surrounding infiltrate rich in Tlymphocytes and histiocytes. Future studies exploring the biology of TCRLBCL and the crosstalk between the neoplastic cells and the surrounding inflammatory infiltrate may provide exciting prospects for future therapies for TCRLBCL. PAGEPress Publications, Pavia, Italy 2015-12-29 /pmc/articles/PMC4703926/ /pubmed/26788280 http://dx.doi.org/10.4081/rt.2015.6084 Text en ©Copyright P. Advani et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Advani, Pooja
Starr, Jason
Swaika, Abhisek
Jiang, Liuyan
Qiu, Yushi
Li, Zhimin
Tun, Han W.
T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma
title T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma
title_full T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma
title_fullStr T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma
title_full_unstemmed T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma
title_short T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma
title_sort t-cell/histiocyte-rich large b-cell lymphoma presenting as a primary central nervous system lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703926/
https://www.ncbi.nlm.nih.gov/pubmed/26788280
http://dx.doi.org/10.4081/rt.2015.6084
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