Cargando…
Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales)
Chemical investigation on the methanol extract of Chaetomium globosum TW1-1, a fungus isolated from the common pillbug (Armadillidium vulgare), has resulted in the isolation of nine new highly oxygenated cytochalasan alkaloids, armochaetoglobins S–Z (1 and 3–9) and 7-O-acetylarmochaetoglobin S (2),...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703973/ https://www.ncbi.nlm.nih.gov/pubmed/26739896 http://dx.doi.org/10.1038/srep18711 |
_version_ | 1782408817539022848 |
---|---|
author | Chen, Chunmei Tong, Qingyi Zhu, Hucheng Tan, Dongdong Zhang, Jinwen Xue, Yongbo Yao, Guangmin Luo, Zengwei Wang, Jianping Wang, Yanyan Zhang, Yonghui |
author_facet | Chen, Chunmei Tong, Qingyi Zhu, Hucheng Tan, Dongdong Zhang, Jinwen Xue, Yongbo Yao, Guangmin Luo, Zengwei Wang, Jianping Wang, Yanyan Zhang, Yonghui |
author_sort | Chen, Chunmei |
collection | PubMed |
description | Chemical investigation on the methanol extract of Chaetomium globosum TW1-1, a fungus isolated from the common pillbug (Armadillidium vulgare), has resulted in the isolation of nine new highly oxygenated cytochalasan alkaloids, armochaetoglobins S–Z (1 and 3–9) and 7-O-acetylarmochaetoglobin S (2), together with eight structurally related known analogues (10–17). Their structures and absolute configurations were elucidated by spectroscopic analyses. Among them, compound 2 presents to be the first member of chaetoglobosin family with an acetyl group, and compounds 3 represents the first chaetoglobosin characterized by an 2′,3′-epoxy-indole moiety. The discovery of these new compounds revealed the largely untapped chemical diversity of cytochalasans and enriched their chemical research. Compounds 1–9 were evaluated for their cytotoxic activities against five human cancer cell lines, and compounds 8 and 9 exhibited significant cytotoxic activities with IC(50) values ranging from 10.45 to 30.42 μM. |
format | Online Article Text |
id | pubmed-4703973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47039732016-01-19 Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales) Chen, Chunmei Tong, Qingyi Zhu, Hucheng Tan, Dongdong Zhang, Jinwen Xue, Yongbo Yao, Guangmin Luo, Zengwei Wang, Jianping Wang, Yanyan Zhang, Yonghui Sci Rep Article Chemical investigation on the methanol extract of Chaetomium globosum TW1-1, a fungus isolated from the common pillbug (Armadillidium vulgare), has resulted in the isolation of nine new highly oxygenated cytochalasan alkaloids, armochaetoglobins S–Z (1 and 3–9) and 7-O-acetylarmochaetoglobin S (2), together with eight structurally related known analogues (10–17). Their structures and absolute configurations were elucidated by spectroscopic analyses. Among them, compound 2 presents to be the first member of chaetoglobosin family with an acetyl group, and compounds 3 represents the first chaetoglobosin characterized by an 2′,3′-epoxy-indole moiety. The discovery of these new compounds revealed the largely untapped chemical diversity of cytochalasans and enriched their chemical research. Compounds 1–9 were evaluated for their cytotoxic activities against five human cancer cell lines, and compounds 8 and 9 exhibited significant cytotoxic activities with IC(50) values ranging from 10.45 to 30.42 μM. Nature Publishing Group 2016-01-07 /pmc/articles/PMC4703973/ /pubmed/26739896 http://dx.doi.org/10.1038/srep18711 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Chen, Chunmei Tong, Qingyi Zhu, Hucheng Tan, Dongdong Zhang, Jinwen Xue, Yongbo Yao, Guangmin Luo, Zengwei Wang, Jianping Wang, Yanyan Zhang, Yonghui Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales) |
title | Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales) |
title_full | Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales) |
title_fullStr | Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales) |
title_full_unstemmed | Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales) |
title_short | Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales) |
title_sort | nine new cytochalasan alkaloids from chaetomium globosum tw1-1 (ascomycota, sordariales) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703973/ https://www.ncbi.nlm.nih.gov/pubmed/26739896 http://dx.doi.org/10.1038/srep18711 |
work_keys_str_mv | AT chenchunmei ninenewcytochalasanalkaloidsfromchaetomiumglobosumtw11ascomycotasordariales AT tongqingyi ninenewcytochalasanalkaloidsfromchaetomiumglobosumtw11ascomycotasordariales AT zhuhucheng ninenewcytochalasanalkaloidsfromchaetomiumglobosumtw11ascomycotasordariales AT tandongdong ninenewcytochalasanalkaloidsfromchaetomiumglobosumtw11ascomycotasordariales AT zhangjinwen ninenewcytochalasanalkaloidsfromchaetomiumglobosumtw11ascomycotasordariales AT xueyongbo ninenewcytochalasanalkaloidsfromchaetomiumglobosumtw11ascomycotasordariales AT yaoguangmin ninenewcytochalasanalkaloidsfromchaetomiumglobosumtw11ascomycotasordariales AT luozengwei ninenewcytochalasanalkaloidsfromchaetomiumglobosumtw11ascomycotasordariales AT wangjianping ninenewcytochalasanalkaloidsfromchaetomiumglobosumtw11ascomycotasordariales AT wangyanyan ninenewcytochalasanalkaloidsfromchaetomiumglobosumtw11ascomycotasordariales AT zhangyonghui ninenewcytochalasanalkaloidsfromchaetomiumglobosumtw11ascomycotasordariales |