Alzheimer’s Model Develops Early ADHD Syndrome

We describe the first invertebrate model of attention deficit hyperactivity disorder (ADHD) that reproduces its major features, including hyperactivity, male predominance, marked exacerbation by simple carbohydrates, reversible response to dextroamphetamine, and a “paradoxical response” to stimulant...

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Detalles Bibliográficos
Autores principales: Zhang, Qiang, Du, Guiping, John, V, Kapahi, Pankaj, Bredesen, Dale E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704098/
https://www.ncbi.nlm.nih.gov/pubmed/26753104
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author Zhang, Qiang
Du, Guiping
John, V
Kapahi, Pankaj
Bredesen, Dale E.
author_facet Zhang, Qiang
Du, Guiping
John, V
Kapahi, Pankaj
Bredesen, Dale E.
author_sort Zhang, Qiang
collection PubMed
description We describe the first invertebrate model of attention deficit hyperactivity disorder (ADHD) that reproduces its major features, including hyperactivity, male predominance, marked exacerbation by simple carbohydrates, reversible response to dextroamphetamine, and a “paradoxical response” to stimulants. This model may offer new insight into ADHD pathogenesis and treatment. Furthermore, these findings are of particular interest in light of the recent epidemiological evidence showing that patients with dementia have a high frequency of antecedent ADHD symptoms.
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spelling pubmed-47040982016-01-07 Alzheimer’s Model Develops Early ADHD Syndrome Zhang, Qiang Du, Guiping John, V Kapahi, Pankaj Bredesen, Dale E. J Neurol Neurophysiol Article We describe the first invertebrate model of attention deficit hyperactivity disorder (ADHD) that reproduces its major features, including hyperactivity, male predominance, marked exacerbation by simple carbohydrates, reversible response to dextroamphetamine, and a “paradoxical response” to stimulants. This model may offer new insight into ADHD pathogenesis and treatment. Furthermore, these findings are of particular interest in light of the recent epidemiological evidence showing that patients with dementia have a high frequency of antecedent ADHD symptoms. 2015 /pmc/articles/PMC4704098/ /pubmed/26753104 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Zhang, Qiang
Du, Guiping
John, V
Kapahi, Pankaj
Bredesen, Dale E.
Alzheimer’s Model Develops Early ADHD Syndrome
title Alzheimer’s Model Develops Early ADHD Syndrome
title_full Alzheimer’s Model Develops Early ADHD Syndrome
title_fullStr Alzheimer’s Model Develops Early ADHD Syndrome
title_full_unstemmed Alzheimer’s Model Develops Early ADHD Syndrome
title_short Alzheimer’s Model Develops Early ADHD Syndrome
title_sort alzheimer’s model develops early adhd syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704098/
https://www.ncbi.nlm.nih.gov/pubmed/26753104
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AT johnv alzheimersmodeldevelopsearlyadhdsyndrome
AT kapahipankaj alzheimersmodeldevelopsearlyadhdsyndrome
AT bredesendalee alzheimersmodeldevelopsearlyadhdsyndrome

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